{"id":"W2168485847","doi":"10.1128/aac.01530-12","title":"The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canada Research Chairs; Cystic Fibrosis Canada; Fundación Alfonso Martín Escudero","keywords":"Operon; Polymyxin; Regulon; Antimicrobial peptides; Two-component regulatory system; Pseudomonas aeruginosa; Bacterial outer membrane; Polymyxin B; Biology; Mutant; Peptide; Antimicrobial; Biochemistry; Chemistry; Cell biology; Microbiology; Bacteria; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002356235,0.0005457631,0.0006026346,0.0003070347,0.0001598509,0.0005602324,0.0003059367,0.0004769919,0.0008631491],"category_scores_gemma":[0.0004386962,0.0002530094,0.0003750556,0.0001728584,0.0003938601,0.0004118971,0.0005647821,0.0008640935,0.0004780329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005579373,"about_ca_system_score_gemma":0.0002684114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007417564,"about_ca_topic_score_gemma":0.0005739264,"domain_scores_codex":[0.999204,0.0001453647,0.00005533916,0.000144574,0.0003324872,0.000118216],"domain_scores_gemma":[0.9996352,0.00006805149,0.0001025225,0.00006052613,0.00006777118,0.00006594594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002169821,0.00000745928,0.00005967809,0.000008148213,0.000001139249,0.00001567362,0.000004606297,0.0000210343,0.9995802,0.00002317284,0.0000112492,0.0002458597],"study_design_scores_gemma":[0.00002288209,0.000290499,0.0104081,0.000005522241,0.00001348209,0.0002947645,0.00005224378,0.002586894,0.9849894,0.00006783866,0.001249241,0.00001906432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937926,0.000469153,0.003904487,0.0002604075,0.00003266483,0.00004793733,0.0003173074,0.0002139186,0.0009615027],"genre_scores_gemma":[0.9934596,0.0002668712,0.003367328,0.0001530201,0.00002232828,0.00008767616,0.0004487699,0.00004064578,0.00215375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008631491,"threshold_uncertainty_score":0.004048169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149121038505443,"score_gpt":0.2299895560463152,"score_spread":0.2184983456612607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}