{"id":"W2168485847","doi":"10.1128/aac.01530-12","title":"The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canada Research Chairs; Cystic Fibrosis Canada; Fundación Alfonso Martín Escudero","keywords":"Operon; Polymyxin; Regulon; Antimicrobial peptides; Two-component regulatory system; Pseudomonas aeruginosa; Bacterial outer membrane; Polymyxin B; Biology; Mutant; Peptide; Antimicrobial; Biochemistry; Chemistry; Cell biology; Microbiology; Bacteria; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003258451,0.0002441916,0.0003802572,0.00008002184,0.0003459742,0.00003933318,0.000141927,0.0001378378,0.00001689423],"category_scores_gemma":[0.00000813182,0.0001827696,0.0000809059,0.0001069813,0.0005382887,0.0001799136,0.00005854179,0.0001984638,0.000009679662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005223615,"about_ca_system_score_gemma":0.0000330957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005335745,"about_ca_topic_score_gemma":0.0002206955,"domain_scores_codex":[0.998675,0.0001541049,0.0003936849,0.0002650803,0.00004952127,0.0004626444],"domain_scores_gemma":[0.9993297,0.0001532035,0.0002451311,0.0001916444,0.00004511801,0.00003519412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003478885,0.0009320147,0.168807,0.0004574845,0.001104004,0.00001627537,0.015033,0.00002072434,0.7466765,0.01872323,0.02585132,0.01889956],"study_design_scores_gemma":[0.01369204,0.000292669,0.3409544,0.001356925,0.0002077734,0.0002846699,0.01337914,0.00002625814,0.5682166,0.0002805748,0.05976622,0.001542778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996009,0.002070198,0.00003278554,0.0006215086,0.0003007819,0.0003268473,0.00004212746,0.00002624652,0.0005705128],"genre_scores_gemma":[0.9954214,0.003187539,0.000154005,0.0003819266,0.00004772147,0.000008929698,0.00001658107,0.00002277231,0.0007590996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1784599,"threshold_uncertainty_score":0.7453128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149121038505443,"score_gpt":0.2299895560463152,"score_spread":0.2184983456612607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}