{"id":"W2168489873","doi":"10.1074/jbc.m311504200","title":"An Immunodominant Epitope of Myelin Basic Protein Is an Amphipathic α-Helix","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Guelph","funders":"National Institute of Biomedical Imaging and Bioengineering; U.S. Public Health Service","keywords":"Helix (gastropod); Epitope; Random coil; Protein secondary structure; Chemistry; Myelin; Myelin basic protein; Lipid bilayer; Biophysics; Bilayer; Protein structure; Alpha helix; Crystallography; Membrane; Biology; Biochemistry; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004347575,0.0001903772,0.0003281035,0.00002467835,0.00004082625,0.00001686787,0.0005418998,0.0003792492,0.0001184406],"category_scores_gemma":[0.0001317179,0.0001345403,0.0002312482,0.00006790033,0.0001714637,0.000011229,0.00006916867,0.0002541037,0.00000541484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002295099,"about_ca_system_score_gemma":0.0001609812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001194275,"about_ca_topic_score_gemma":0.00000110444,"domain_scores_codex":[0.9986843,0.00006214438,0.0005951956,0.0002661868,0.0001638305,0.0002283772],"domain_scores_gemma":[0.9987228,0.000006934106,0.0004371659,0.0003719178,0.0003011006,0.0001601177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004552137,0.0002818555,0.0005206127,0.00002513303,0.00004557706,0.00002426321,0.00006482399,0.00003787352,0.9952279,0.00000452804,0.0000283499,0.003283908],"study_design_scores_gemma":[0.0007587931,0.002366793,0.001576097,0.00008571975,0.00001534934,0.0001558653,0.0002150348,0.000004779995,0.9935529,0.0004748994,0.0006119634,0.0001817535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997468,0.00181999,0.0003463304,0.0001182627,0.00006457588,0.00007280182,0.00002277366,0.000004477902,0.0000827917],"genre_scores_gemma":[0.9976876,0.0006434739,0.0009565725,0.0001801396,0.0004460974,0.000003847807,0.00003078601,0.00001164592,0.0000398489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003102154,"threshold_uncertainty_score":0.5486394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223665266705997,"score_gpt":0.2695742689104133,"score_spread":0.2472077422398136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}