{"id":"W2168489873","doi":"10.1074/jbc.m311504200","title":"An Immunodominant Epitope of Myelin Basic Protein Is an Amphipathic α-Helix","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Guelph","funders":"National Institute of Biomedical Imaging and Bioengineering; U.S. Public Health Service","keywords":"Helix (gastropod); Epitope; Random coil; Protein secondary structure; Chemistry; Myelin; Myelin basic protein; Lipid bilayer; Biophysics; Bilayer; Protein structure; Alpha helix; Crystallography; Membrane; Biology; Biochemistry; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004941713,0.0001425245,0.00008068424,0.00008766152,0.0001349431,0.00010721,0.00008454554,0.0001471579,0.0005978516],"category_scores_gemma":[0.00005067481,0.00005297385,0.00007089118,0.000062815,0.0001255951,0.00009613852,0.00008823458,0.0001385397,0.000529231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112728,"about_ca_system_score_gemma":0.0000730377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001453178,"about_ca_topic_score_gemma":0.0001923718,"domain_scores_codex":[0.9999708,0.00000326271,0.00000113497,0.000008303272,0.00001057279,0.0000058444],"domain_scores_gemma":[0.9999739,0.000003538712,0.000007543365,0.000001698194,0.000004218112,0.000009196534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000293143,0.000004251473,0.0002026869,0.00001175548,8.007854e-7,0.00004254639,0.00000790806,0.00003209393,0.997597,0.0001391877,0.00002036257,0.001912037],"study_design_scores_gemma":[0.00001391118,0.000463243,0.009560928,0.000008986462,0.00001007189,0.001298557,0.00004742685,0.0009778702,0.9795084,0.00041985,0.007685477,0.000005372319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991119,0.001331119,0.005544749,0.00007210961,0.0000118135,0.00001122555,0.00008417968,0.00005305521,0.001772733],"genre_scores_gemma":[0.99419,0.0006210061,0.003195632,0.00003831517,0.000007975283,0.000004781705,0.0001407082,0.000005963108,0.001795642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005978516,"threshold_uncertainty_score":0.002000034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223665266705997,"score_gpt":0.2695742689104133,"score_spread":0.2472077422398136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}