{"id":"W2168540377","doi":"10.1128/mcb.01102-14","title":"Panspecies Small-Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust","keywords":"Heterochromatin; Biology; Heterochromatin protein 1; EZH2; RNA-induced transcriptional silencing; Histone methyltransferase; Schizosaccharomyces; Chromatin; Histone; Schizosaccharomyces pombe; DNA methylation; Histone methylation; Genetics; Gene silencing; Molecular biology; RNA interference; Gene expression; Gene; Saccharomyces cerevisiae; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478087,0.000533511,0.0003194669,0.0002464597,0.0001413315,0.0002296873,0.0003349562,0.0003235815,0.002369161],"category_scores_gemma":[0.00006276027,0.000220189,0.0002783155,0.0001556884,0.0001541048,0.0001548745,0.0002031508,0.000557479,0.0004748778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004108094,"about_ca_system_score_gemma":0.0002143021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004913936,"about_ca_topic_score_gemma":0.001342888,"domain_scores_codex":[0.9998779,0.00001221263,0.000009922494,0.00003385736,0.00004178646,0.00002428832],"domain_scores_gemma":[0.9999461,0.000007554148,0.0000168994,0.000007848153,0.00000655657,0.00001496306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003653293,0.0000179404,0.00002966675,0.00002002885,0.000004509341,0.0000104433,0.000003004694,0.00002688946,0.9987181,0.00008266266,0.00002781529,0.001022357],"study_design_scores_gemma":[0.0000240703,0.0003650167,0.0009464184,0.0000024544,0.00001363371,0.0001018426,0.000004208659,0.00032389,0.9949327,0.00001793972,0.003264728,0.000003077993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725627,0.004611535,0.01070139,0.0001754507,0.00007854179,0.0002651101,0.001471497,0.0006933606,0.009440511],"genre_scores_gemma":[0.9814969,0.002661008,0.005258523,0.0001084788,0.00001720015,0.0001931724,0.001796208,0.00005256801,0.008415952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002369161,"threshold_uncertainty_score":0.00792563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282769805839144,"score_gpt":0.2024671603310684,"score_spread":0.1896394622726769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}