{"id":"W2168557022","doi":"10.4049/jimmunol.171.3.1272","title":"Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent Mechanism","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":323,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Blockade; Immunology; Graft-versus-host disease; Perforin; Fas ligand; Autoimmunity; Disease; Lethality; Ligation; Medicine; Cancer research; Apoptosis; Biology; Receptor; Antigen; Programmed cell death; Immune system; Internal medicine; CD8; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001742846,0.0001690992,0.0004041547,0.00009854652,0.00009117588,0.00001067156,0.0002447273,0.00009692759,0.0002377651],"category_scores_gemma":[0.000197404,0.0001121738,0.0001139674,0.0001095281,0.0001205401,0.00009256704,0.00002128685,0.0004384977,0.000008113271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007935445,"about_ca_system_score_gemma":0.0002012159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004362859,"about_ca_topic_score_gemma":0.000005984961,"domain_scores_codex":[0.9976731,0.0008705266,0.000670556,0.0001244565,0.0003820723,0.0002792997],"domain_scores_gemma":[0.9984928,0.0002960341,0.0004599293,0.0003550764,0.0002442442,0.0001519471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007070477,0.001637728,0.003287696,0.0002153697,0.001257366,0.0001923544,0.003221416,0.0000157549,0.9756422,0.005942598,0.00008651946,0.001430514],"study_design_scores_gemma":[0.009570677,0.003221329,0.01492997,0.0001878516,0.00156156,0.00088247,0.003611578,0.00001994101,0.9627085,0.002040262,0.001054928,0.000210938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932959,0.00168634,0.002919998,0.0008905142,0.0004098595,0.0004320445,0.00001132297,0.00001601138,0.000338014],"genre_scores_gemma":[0.9978547,0.0008509886,0.001033691,0.00008055654,0.00003896115,0.000008297792,0.00001026385,0.00002101965,0.0001015563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01293371,"threshold_uncertainty_score":0.4574313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04477870981226403,"score_gpt":0.3063086534245244,"score_spread":0.2615299436122603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}