{"id":"W2168565140","doi":"10.1158/1078-0432.ccr-06-1485","title":"Variants of the hK2 Protein Gene (<i>KLK2</i>) Are Associated with Serum hK2 Levels and Predict the Presence of Prostate Cancer at Biopsy","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; University Health Network","funders":"","keywords":"Prostate cancer; Prostate; Medicine; Oncology; Cancer; Biopsy; Gene; Internal medicine; Biology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002377408,0.0001732848,0.0005015892,0.00006388623,0.0002661915,0.00002306654,0.0003239416,0.0001737786,0.0003061664],"category_scores_gemma":[0.001197115,0.00009057369,0.0001218471,0.0007741213,0.001559113,0.00007641199,0.000288421,0.0005467859,0.000001534935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334447,"about_ca_system_score_gemma":0.000826781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003756128,"about_ca_topic_score_gemma":0.003059106,"domain_scores_codex":[0.9966063,0.0005397209,0.00073325,0.000456828,0.001154146,0.0005097],"domain_scores_gemma":[0.9969881,0.0009412279,0.0004344205,0.0005943435,0.0008986678,0.0001432878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009885901,0.0002642804,0.9889315,0.0001752794,0.0001660408,0.000006806744,0.0002433279,0.00005100091,0.004738208,0.00008737512,0.002402569,0.001944981],"study_design_scores_gemma":[0.002451513,0.0003805486,0.9763764,0.001134515,0.00008220957,0.000005838146,0.00006656946,0.0005181474,0.017415,0.0003264977,0.001138578,0.0001041937],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873193,0.003735395,0.000004809938,0.006123029,0.0001138661,0.001855276,0.000488469,0.00002064144,0.0003392321],"genre_scores_gemma":[0.9834981,0.0002849823,0.00002693897,0.00006874109,0.000264847,0.0002242256,0.000008786777,0.00003298243,0.01559041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01525118,"threshold_uncertainty_score":0.5744616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1128545819242357,"score_gpt":0.4095499342154282,"score_spread":0.2966953522911925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}