{"id":"W2168598580","doi":"10.1158/1940-6207.capr-10-0073","title":"Premalignant Breast Neoplasia: A Paradigm of Interlesional and Intralesional Molecular Heterogeneity and Its Biological and Clinical Ramifications","year":2010,"lang":"en","type":"review","venue":"Cancer Prevention Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Phenotype; Carcinogenesis; Breast cancer; Mammary gland; Disease; Biology; Pathology; Cancer research; Medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007432094,0.001010632,0.00141272,0.00250984,0.0003209267,0.001239439,0.001041989,0.001486334,0.001935875],"category_scores_gemma":[0.0006656278,0.0002704737,0.0002976158,0.002936345,0.001127409,0.002329322,0.0007614619,0.002095948,0.002386854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001153775,"about_ca_system_score_gemma":0.001164927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323801,"about_ca_topic_score_gemma":0.002379468,"domain_scores_codex":[0.9998186,0.00003654198,0.00002226637,0.00003556683,0.00007102029,0.00001593497],"domain_scores_gemma":[0.9996277,0.0001630743,0.0000468131,0.00001509747,0.0001002922,0.00004697857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006900472,0.00004981988,0.0002371139,0.009028781,0.00006121454,0.0003586173,0.00008106053,0.0003717853,0.002064591,0.01037581,0.05728423,0.920018],"study_design_scores_gemma":[0.000009355161,0.00004087429,0.0005859287,0.00141821,0.00003508943,0.00196813,0.00007814685,0.00005970052,0.000307532,0.003428218,0.9920532,0.00001568041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005876819,0.9983699,0.0001542202,0.0003430726,0.0002244681,0.000002729137,0.000007844215,0.000005772984,0.0008333362],"genre_scores_gemma":[0.0003806041,0.9984332,0.0001893862,0.0002221037,0.0001956764,0.000004686982,0.00001311654,0.00000127168,0.0005599904],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00250984,"threshold_uncertainty_score":0.008371294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1598907099977788,"score_gpt":0.49070211473245,"score_spread":0.3308114047346712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}