{"id":"W2168640804","doi":"10.1074/jbc.m511546200","title":"Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); Concordia University","funders":"","keywords":"Active site; Binding site; Biochemistry; Yeast; Amino acid; Enzyme; Protein tyrosine phosphatase; Tyrosine; Inhibitor protein; Chemistry; Potency; Mutant; Enzyme inhibitor; Moiety; Alanine scanning; Biology; Stereochemistry; Mutagenesis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199434,0.0004178737,0.0005141177,0.0002150011,0.0001480008,0.0003608493,0.0002298941,0.0002595873,0.001481654],"category_scores_gemma":[0.000165116,0.0002224153,0.0002661171,0.0002030741,0.000126921,0.0001236636,0.0001807537,0.0003836791,0.0005044458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514981,"about_ca_system_score_gemma":0.0002010624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009607643,"about_ca_topic_score_gemma":0.001689403,"domain_scores_codex":[0.9998411,0.00001802879,0.00001167642,0.00003012811,0.00006617545,0.00003285151],"domain_scores_gemma":[0.9999141,0.00002509346,0.00002895131,0.000005395743,0.000007802996,0.00001871811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009749091,0.00004376327,0.0003778669,0.00002012178,0.000009119661,0.00007308072,0.000006363562,0.0002438755,0.9975823,0.0000317113,0.00001492517,0.001499324],"study_design_scores_gemma":[0.00003064735,0.0004709045,0.00887338,0.000005589074,0.00005575698,0.0006965576,0.00001958974,0.00193345,0.9864071,0.00002739038,0.001470831,0.000008774903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967318,0.0006873431,0.001255371,0.00002440225,0.000007615239,0.00002155661,0.0002563496,0.00005669373,0.0009589086],"genre_scores_gemma":[0.9963367,0.0005689936,0.001605715,0.00003075544,0.000004365727,0.00001502912,0.0005893871,0.00001862328,0.0008303232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481654,"threshold_uncertainty_score":0.004956603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144867813251809,"score_gpt":0.2446855341010551,"score_spread":0.233236855968537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}