{"id":"W2168648244","doi":"10.1186/s12977-015-0159-3","title":"Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis","year":2015,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Viral replication; Viral load; Raltegravir; Virology; Medicine; RNA; Drug; Viral entry; Integrase inhibitor; Viral shedding; Virus; Biology; Antiretroviral therapy; Pharmacology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124082,0.0005003428,0.000329127,0.0001804738,0.0001432525,0.0003617683,0.0003197305,0.0003668246,0.001060088],"category_scores_gemma":[0.00009299212,0.0001347613,0.0002943958,0.0001078404,0.0002729321,0.000266932,0.0001609807,0.000859149,0.0003778848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635864,"about_ca_system_score_gemma":0.0002200629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002517392,"about_ca_topic_score_gemma":0.000361623,"domain_scores_codex":[0.9998276,0.00003181998,0.00001869576,0.00003480393,0.00004250616,0.00004441165],"domain_scores_gemma":[0.9998845,0.00002313478,0.00003855581,0.00002023368,0.00001196854,0.00002166315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333037,0.00007835848,0.00007940654,0.00002820725,0.000005305588,0.0000335211,0.000007522976,0.00008804351,0.997331,0.00008745823,0.00003673365,0.002091164],"study_design_scores_gemma":[0.0000393747,0.001151862,0.0007398826,0.000003443733,0.00001321193,0.0002222051,0.000005729386,0.0007043369,0.9954939,0.00002511209,0.001596898,0.000004141874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905382,0.002956653,0.004284165,0.0001298064,0.00005842252,0.00005923003,0.0002044041,0.0001892722,0.001579733],"genre_scores_gemma":[0.9901923,0.001266806,0.004940506,0.00006553977,0.0000223197,0.0000622074,0.000345434,0.00002661962,0.003078287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060088,"threshold_uncertainty_score":0.003546357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122279793184836,"score_gpt":0.2367434725305003,"score_spread":0.2245154932120167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}