{"id":"W2168693839","doi":"10.1083/jcb.200504028","title":"A local mechanism mediates NAD-dependent protection of axon degeneration","year":2005,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa","funders":"","keywords":"Wallerian degeneration; NAD+ kinase; Axon; Biology; Degeneration (medical); Nicotinamide adenine dinucleotide; Nicotinamide mononucleotide; Neuroscience; Soma; Cell biology; Biochemistry; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443682,0.0003657518,0.0004569107,0.0001609687,0.0002492263,0.0003759958,0.0003267316,0.0004140666,0.001355996],"category_scores_gemma":[0.000121243,0.0001161537,0.0003750444,0.00008230936,0.000378427,0.0004086886,0.0004051466,0.0004897736,0.0006168428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220953,"about_ca_system_score_gemma":0.0001887919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003359117,"about_ca_topic_score_gemma":0.001449408,"domain_scores_codex":[0.9998919,0.00001733817,0.000008486581,0.00003937831,0.00002021377,0.00002263636],"domain_scores_gemma":[0.9998819,0.00001116979,0.00002959667,0.00002754409,0.00002587787,0.00002404047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001018804,0.00001472164,0.0005070443,0.0001349158,0.0000192579,0.0001669917,0.00003306443,0.00006544753,0.99387,0.0005646388,0.00005394375,0.004468036],"study_design_scores_gemma":[0.00003615557,0.0007848432,0.01719344,0.00003858233,0.00007307256,0.001052025,0.0001632077,0.0008171549,0.9728391,0.000669045,0.006318987,0.00001432684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952045,0.01342388,0.02681394,0.0003405046,0.0001321342,0.00004890985,0.0002479377,0.0005621096,0.006385652],"genre_scores_gemma":[0.9908641,0.002435317,0.003031123,0.00005707645,0.00002620445,0.00002189668,0.0001844173,0.0000159232,0.003363873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001355996,"threshold_uncertainty_score":0.004536271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450760642551975,"score_gpt":0.252910333282922,"score_spread":0.2384027268574022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}