{"id":"W2168710841","doi":"10.1074/jbc.m110.175406","title":"Possible Roles of Exceptionally Conserved Residues around the Selectivity Filters of Sodium and Calcium Channels","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Selectivity; Chemistry; Crystallography; Stereochemistry; Helix (gastropod); Ion channel; Biophysics; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003265916,0.00008957696,0.0002071514,0.00001067907,0.00005444576,0.000009389786,0.0001477588,0.0001403,0.00002537092],"category_scores_gemma":[0.0002595205,0.000052688,0.0001048192,0.0000374177,0.0003480503,0.000003472883,0.00007356436,0.0001599111,1.510613e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000360061,"about_ca_system_score_gemma":0.00005447257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004392342,"about_ca_topic_score_gemma":0.00000828313,"domain_scores_codex":[0.9993806,0.00003487956,0.0002914325,0.0001022384,0.00009428589,0.00009655982],"domain_scores_gemma":[0.9992722,0.00005110994,0.0003292302,0.00009345216,0.0002087614,0.00004519199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001739819,0.00007157724,0.01655048,0.00002653431,0.0000616954,0.000001216136,0.00003782108,0.000003298929,0.9826753,0.00002295183,0.0002284416,0.0001467619],"study_design_scores_gemma":[0.0003191876,0.0003372052,0.03888486,0.00001324901,0.00001473154,0.00009323693,0.0002420207,0.00001205039,0.9588786,0.0003300958,0.000805339,0.00006941784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983729,0.0006209755,0.00005781891,0.0004010874,0.00004328294,0.00003531189,0.00001531302,0.000001701924,0.0004515927],"genre_scores_gemma":[0.999218,0.0001813553,0.000217429,0.000054425,0.000210074,0.000001410985,0.000005249495,0.000003442902,0.0001086167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02379663,"threshold_uncertainty_score":0.2148554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517825770651608,"score_gpt":0.2641666671768618,"score_spread":0.2389884094703457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}