{"id":"W2168719284","doi":"10.1093/jac/dku149","title":"Pharmacodynamic activity of ertapenem versus genotypically characterized extended-spectrum  -lactamase (ESBL)-, KPC- or NDM-producing Escherichia coli with reduced susceptibility or resistance to ertapenem using an in vitro model","year":2014,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"Health Canada; Merck Canada","keywords":"Ertapenem; Microbiology; Minimum inhibitory concentration; Antibacterial agent; Pharmacodynamics; Escherichia coli; Biology; Antibiotics; Meropenem; Pharmacokinetics; Antibiotic resistance; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057846,0.0004767624,0.0004319151,0.0001254628,0.00006145449,0.000364577,0.0002153739,0.0002857391,0.0009787597],"category_scores_gemma":[0.0004732019,0.0001299683,0.0002220123,0.0001712089,0.0001590047,0.0002147726,0.0001144931,0.0004297178,0.0001697542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458425,"about_ca_system_score_gemma":0.0001771101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006685769,"about_ca_topic_score_gemma":0.0006635484,"domain_scores_codex":[0.9997876,0.00007298087,0.00002151525,0.00003751492,0.0000498579,0.00003044301],"domain_scores_gemma":[0.9996992,0.00007832313,0.000103075,0.00002479647,0.00005511872,0.00003935845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001902306,0.0003379337,0.00116159,0.0001046931,0.00003556606,0.00006502103,0.00001582726,0.0006134027,0.9925235,0.00001200515,0.00006080548,0.003167344],"study_design_scores_gemma":[0.0001456539,0.02105541,0.01762968,0.00000847636,0.0001294065,0.0007294922,0.00003575599,0.003166287,0.9561878,0.00002043754,0.0008763921,0.00001519711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981835,0.0005966357,0.0006072538,0.00003191377,0.000008449883,0.00002241187,0.0002513324,0.00001164099,0.0002868692],"genre_scores_gemma":[0.9965575,0.000842553,0.00113002,0.00004253819,0.00001764522,0.00002536002,0.0007055777,0.0000078617,0.0006709549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009787597,"threshold_uncertainty_score":0.003274322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919104211193754,"score_gpt":0.2896309023236662,"score_spread":0.2704398602117286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}