{"id":"W2168724697","doi":"10.3109/0886022x.2011.618970","title":"Bardoxolone Methyl: A Targeted Antioxidant","year":2011,"lang":"en","type":"article","venue":"Renal Failure","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Oxidative stress; Xanthine oxidase; Reactive oxygen species; Medicine; Proinflammatory cytokine; Pharmacology; Biochemistry; NAD+ kinase; Superoxide dismutase; KEAP1; Transcription factor; Biology; Enzyme; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007187486,0.0003744156,0.0002573436,0.0002865332,0.0001340245,0.0002204625,0.0003397171,0.0003249668,0.002243975],"category_scores_gemma":[0.00002655259,0.00008275552,0.0001246909,0.0001601176,0.0001025186,0.0002176805,0.0001859662,0.0004857903,0.0006744559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422442,"about_ca_system_score_gemma":0.0001770592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000544165,"about_ca_topic_score_gemma":0.0009683887,"domain_scores_codex":[0.9999652,0.000003896085,0.000001849734,0.00001195862,0.000009139962,0.000007819979],"domain_scores_gemma":[0.9999875,6.086315e-7,0.000003074314,7.891967e-7,0.000002651883,0.000005410537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087839,0.000343923,0.0002597575,0.0005857881,0.00002736717,0.0003267221,0.00001991352,0.0002339438,0.9140916,0.001303115,0.003079568,0.07864039],"study_design_scores_gemma":[0.001077879,0.006407855,0.004551408,0.0001291256,0.0001565125,0.002504858,0.00002282756,0.00157546,0.7422864,0.0005151107,0.2407326,0.0000399715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6888419,0.2474002,0.0208542,0.004095241,0.001639455,0.0007225291,0.002251048,0.001443882,0.03275162],"genre_scores_gemma":[0.8899962,0.07075813,0.01076176,0.00135323,0.0002483492,0.0003175404,0.001417516,0.00003444413,0.02511283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243975,"threshold_uncertainty_score":0.007506788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502275863689502,"score_gpt":0.2240285848738986,"score_spread":0.2090058262370036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}