{"id":"W2168724697","doi":"10.3109/0886022x.2011.618970","title":"Bardoxolone Methyl: A Targeted Antioxidant","year":2011,"lang":"en","type":"article","venue":"Renal Failure","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Oxidative stress; Xanthine oxidase; Reactive oxygen species; Medicine; Proinflammatory cytokine; Pharmacology; Biochemistry; NAD+ kinase; Superoxide dismutase; KEAP1; Transcription factor; Biology; Enzyme; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008646725,0.0001756548,0.0001695471,0.00003673274,0.00005634167,0.0000112267,0.0002276538,0.0001646547,0.0001531699],"category_scores_gemma":[0.00004672002,0.0001597528,0.0001282364,0.00007405073,0.00009733532,0.000003545207,0.0001109505,0.0001002762,0.0000402759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008417484,"about_ca_system_score_gemma":0.00004110449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003378818,"about_ca_topic_score_gemma":0.0000390732,"domain_scores_codex":[0.9990331,0.00004991574,0.0001796631,0.0003629948,0.00009528307,0.000279034],"domain_scores_gemma":[0.9993757,0.000005179861,0.00007394807,0.0003415221,0.00008637749,0.000117264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007819121,0.00005388348,0.0005268337,0.000008755143,0.00007970044,0.000007321031,0.00007737627,8.862225e-7,0.9904148,0.0002570101,0.007946752,0.0005485156],"study_design_scores_gemma":[0.0003509834,0.0001408443,0.0037448,0.00001073919,0.00002039023,0.00001442978,0.00006065426,0.000004948671,0.9278318,0.0005884632,0.06701569,0.0002162755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891585,0.001365493,0.004806729,0.0001672546,0.0001094131,0.0001334534,0.00006415845,0.00002993358,0.004165109],"genre_scores_gemma":[0.9918346,0.0001042279,0.006784614,0.0002346698,0.0002673807,0.00001624335,0.0001119903,0.00002557782,0.0006206365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06258298,"threshold_uncertainty_score":0.6514528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502275863689502,"score_gpt":0.2240285848738986,"score_spread":0.2090058262370036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}