{"id":"W2168767754","doi":"10.1016/j.bpj.2013.11.3793","title":"Destabilizing Amyloid Fibrils by Selective Sequence Mutations Enabled by Computational Assembly of Polymorphic Structures","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Fibril; Amylin; Amyloid (mycology); Chemistry; Point mutation; Biophysics; Protein aggregation; Peptide sequence; Amyloid fibril; Mutant; Amino acid; Biochemistry; Protein folding; Biology; Amyloid β; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902264,0.0005324071,0.0005243121,0.0002750333,0.0004920262,0.0006066291,0.0006373412,0.0005028606,0.001033051],"category_scores_gemma":[0.0008452305,0.0003841467,0.0003650956,0.0002143845,0.0003553659,0.000536455,0.0004375634,0.000924419,0.0001611341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004538889,"about_ca_system_score_gemma":0.0006744505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002402167,"about_ca_topic_score_gemma":0.002864895,"domain_scores_codex":[0.9999146,0.00002319373,0.000004212138,0.00001515473,0.0000200184,0.00002278568],"domain_scores_gemma":[0.9997076,0.0001431972,0.00004260918,0.00002923072,0.00004489529,0.00003235852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003067999,0.0001973348,0.002116485,0.000125514,0.00006050749,0.0003246214,0.0001284686,0.9557646,0.02687283,0.005557285,0.0006170959,0.007928425],"study_design_scores_gemma":[0.00002973341,0.00005373873,0.0001896701,0.000004062155,0.00001408857,0.00001756978,0.000021457,0.9951846,0.003275334,0.001035452,0.0001677707,0.000006480783],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796965,0.0001451135,0.01677789,0.0001187795,0.00003728138,0.00002435047,0.00007410356,0.0002639223,0.002862112],"genre_scores_gemma":[0.9925252,0.000103734,0.006981501,0.00002702473,0.000006581693,0.00002724879,0.00008111282,0.00005086004,0.000196657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002402167,"threshold_uncertainty_score":0.004776418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285822312109281,"score_gpt":0.3121434004255442,"score_spread":0.2892851773044514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}