{"id":"W2168780544","doi":"10.1007/s00285-012-0608-8","title":"Dynamics and stability of a three-dimensional model of cell signal transduction","year":2012,"lang":"en","type":"article","venue":"Journal of Mathematical Biology","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Ordinary differential equation; Stability (learning theory); Differential equation; Signal transduction; Exponential stability; Signalling; Control theory (sociology); Mathematics; Cytosol; SIGNAL (programming language); Hysteresis; Biological system; Signalling pathways; Dynamics (music); Applied mathematics; Mathematical analysis; Physics; Computer science; Biology; Cell biology; Nonlinear system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000484335,0.0007161064,0.001097461,0.0008847725,0.001067863,0.002382173,0.001498824,0.002206529,0.003138081],"category_scores_gemma":[0.00196451,0.0004887925,0.0009837877,0.0005392077,0.002162834,0.001287888,0.001242897,0.001146792,0.0003259553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002150685,"about_ca_system_score_gemma":0.001148704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01149027,"about_ca_topic_score_gemma":0.003746951,"domain_scores_codex":[0.9997965,0.00006835297,0.00000858259,0.00003946139,0.00004886466,0.00003833746],"domain_scores_gemma":[0.9991664,0.0003766661,0.0001635578,0.00003801778,0.00009765754,0.0001578155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001547338,0.00009317385,0.001061088,0.00004338035,0.00006997326,0.000171377,0.0001465782,0.8459397,0.007869874,0.1419774,0.0006540163,0.00181878],"study_design_scores_gemma":[0.00001369161,0.00001378992,0.0001390297,0.00000203202,0.00000722537,0.00001472465,0.00001245619,0.9888942,0.0001718067,0.01059985,0.0001205197,0.00001084787],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7160104,0.0005988355,0.2567307,0.002842532,0.0001382638,0.00006962853,0.0004819696,0.000297463,0.02283027],"genre_scores_gemma":[0.9874443,0.0002475873,0.006791881,0.0001046405,0.00003110795,0.00007107946,0.0001006254,0.0000295572,0.005179245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01149027,"threshold_uncertainty_score":0.02284682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596801977585116,"score_gpt":0.2386302864618858,"score_spread":0.2226622666860347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}