{"id":"W2168807338","doi":"10.1002/mnfr.200600300","title":"Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and<i>Echinacea</i>","year":2008,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"Medicinal Plant Extracts Effects","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Silybum marianum; Hypericum perforatum; Kava; Milk Thistle; Black cohosh; Traditional medicine; Phytotherapy; Medicine; Echinacea (animal); Pharmacology; CYP2D6; Cytochrome P450; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002833338,0.0003025557,0.001052572,0.001087854,0.0001124663,0.00001622087,0.0002515012,0.0001987412,0.00008784667],"category_scores_gemma":[0.002108612,0.0002850181,0.0002430243,0.001093263,0.001017468,0.0001383402,0.0001547104,0.00207883,0.00002175139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211419,"about_ca_system_score_gemma":0.00044794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212332,"about_ca_topic_score_gemma":0.0002371323,"domain_scores_codex":[0.9938433,0.001807336,0.001171679,0.0006827972,0.001854302,0.0006406149],"domain_scores_gemma":[0.994809,0.003066714,0.0002863595,0.0006730007,0.000700755,0.0004641949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003647223,0.01746113,0.1190835,0.01602829,0.001026056,0.01212348,0.00150183,0.00002370489,0.7669392,0.001059489,0.05979449,0.001311638],"study_design_scores_gemma":[0.04413382,0.02172354,0.6401495,0.02277714,0.000633506,0.001146361,0.001363751,0.00256225,0.248481,0.00114322,0.01470046,0.001185497],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898542,0.003511687,0.0002486177,0.001269249,0.000187531,0.002738433,0.00005283101,0.00004384419,0.002093603],"genre_scores_gemma":[0.9940487,0.003686205,0.00120732,0.0002153657,0.0001307567,0.0001224014,0.0002364519,0.00005610501,0.0002967457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.521066,"threshold_uncertainty_score":0.9999602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06607216672291924,"score_gpt":0.4243829211753984,"score_spread":0.3583107544524792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}