{"id":"W2168836088","doi":"10.1128/aac.49.7.2657-2664.2005","title":"Impaired Rescue of Chain-Terminated DNA Synthesis Associated with the L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Zidovudine; Biology; Primer (cosmetics); Resistance mutation; Virology; Didanosine; DNA; Molecular biology; Mutation; Nucleoside analogue; Nucleotidyltransferase; DNA polymerase; Virus; Nucleoside; Genetics; Gene; Chemistry; Polymerase chain reaction; RNA; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690519,0.0004718456,0.0003612121,0.0002806717,0.0001404863,0.0002791306,0.0003265064,0.0004769922,0.001181671],"category_scores_gemma":[0.0002880984,0.0002147229,0.0003812714,0.0001261117,0.0002809702,0.0001498195,0.0002340378,0.0005617518,0.0004436348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272274,"about_ca_system_score_gemma":0.0001988313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006767201,"about_ca_topic_score_gemma":0.0005134808,"domain_scores_codex":[0.9997719,0.00005785556,0.00002938457,0.00003446887,0.00006100057,0.00004531068],"domain_scores_gemma":[0.9997602,0.00007171545,0.00007331978,0.0000403807,0.00002031794,0.00003419759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006030222,0.00003790525,0.0002176918,0.0000238682,0.00000789095,0.00009039917,0.00001423903,0.000106228,0.9983935,0.00007194786,0.00001983073,0.0009562823],"study_design_scores_gemma":[0.00001811686,0.0005527428,0.003647755,0.000006682883,0.00001645929,0.0004822277,0.0000208052,0.00120858,0.9928762,0.00004604343,0.001117662,0.000006791659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980708,0.0004032464,0.0009185845,0.00002659201,0.00001540894,0.00001619411,0.0001645402,0.00004942146,0.0003353099],"genre_scores_gemma":[0.9968295,0.0002671357,0.00132008,0.00002510031,0.000008286175,0.00001923711,0.0004806275,0.00002956118,0.001020507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181671,"threshold_uncertainty_score":0.00395304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405875232755118,"score_gpt":0.2531702039366334,"score_spread":0.2391114516090822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}