{"id":"W2168842568","doi":"10.1093/intimm/dxm113","title":"Constitutive Notch signalling promotes CD4-CD8- thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals","year":2007,"lang":"en","type":"article","venue":"International Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canada Research Chairs","keywords":"Thymocyte; T-cell receptor; Double negative; Cell biology; CD8; Signalling; MAPK/ERK pathway; Notch signaling pathway; T cell; Biology; Lymphocyte; Lymphopoiesis; Chemistry; Signal transduction; Cancer research; Immunology; Antigen; Stem cell; Immune system; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006489974,0.0002015204,0.000149763,0.0001021341,0.00007172143,0.0002576242,0.0001587735,0.0001459391,0.0009972061],"category_scores_gemma":[0.00006260098,0.0000836374,0.00008562138,0.00007352028,0.00009213375,0.0001177089,0.0001763144,0.0004406187,0.0004746479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170226,"about_ca_system_score_gemma":0.0001372595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930489,"about_ca_topic_score_gemma":0.0007546145,"domain_scores_codex":[0.9998925,0.00001399837,0.00001318043,0.00002430016,0.0000313079,0.00002457882],"domain_scores_gemma":[0.9999306,0.000009355288,0.00001818475,0.000007836461,0.000006867916,0.00002699291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004867351,0.00001448939,0.00007585339,0.00001564395,9.232056e-7,0.00002959721,0.000007829217,0.0000281777,0.999275,0.00004331408,0.000009761447,0.0004506931],"study_design_scores_gemma":[0.000006044976,0.0001105459,0.001258317,0.000004458306,0.000005068398,0.0001248763,0.0000117775,0.0003584557,0.9966145,0.0000165134,0.001488078,0.000001277679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957626,0.0008095542,0.001204389,0.00002348175,0.00001551664,0.00002185369,0.0001982892,0.00004195474,0.001922315],"genre_scores_gemma":[0.9945847,0.0004451492,0.001349503,0.00002150353,0.00000608578,0.00001989404,0.0002772239,0.00001671155,0.003279187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009972061,"threshold_uncertainty_score":0.003336012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779770282047523,"score_gpt":0.2609659139975939,"score_spread":0.2431682111771186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}