{"id":"W2168850976","doi":"10.1128/aac.44.5.1127-1131.2000","title":"Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants Resistant to the (+) and (−) Enantiomers of 2′-Deoxy-3′-Oxa-4′-Thio-5-Fluorocytidine","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Medical Research Council Canada","keywords":"Resistance mutation; Biology; Virology; Mutation; Virus; clone (Java method); Mutagenesis; Genetics; Recombinant DNA; Reverse transcriptase; Molecular biology; Gene; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348879,0.0002173075,0.0002443409,0.0001296553,0.0001217835,0.0002656451,0.0001923689,0.0001800012,0.0004967646],"category_scores_gemma":[0.0002755104,0.0001341399,0.000208773,0.0001776513,0.000099045,0.00006575996,0.00009623914,0.0002651992,0.0002074497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461713,"about_ca_system_score_gemma":0.0001146318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019526,"about_ca_topic_score_gemma":0.001833985,"domain_scores_codex":[0.9998707,0.00002798578,0.00001416266,0.00002629292,0.00003916131,0.00002167818],"domain_scores_gemma":[0.9998895,0.00002691741,0.0000240141,0.00001790383,0.0000188811,0.00002293654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006884521,0.00003894178,0.00128373,0.00001224721,0.00000629366,0.0001594238,0.00003643288,0.0001264791,0.9966959,0.00005165707,0.0000296572,0.001490412],"study_design_scores_gemma":[0.00004888423,0.001344485,0.03365138,0.000008144786,0.00004975715,0.003551505,0.000126191,0.002910106,0.9546476,0.00004397373,0.00359613,0.00002182934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984214,0.000198995,0.0006818372,0.00001400903,0.000006617662,0.00002956968,0.0002756861,0.000008558077,0.0003632257],"genre_scores_gemma":[0.9948891,0.0002684933,0.002696435,0.00002880252,0.000007996738,0.00002467899,0.0009802541,0.00001938786,0.001084949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019526,"threshold_uncertainty_score":0.003882468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135653853746671,"score_gpt":0.2534932252786532,"score_spread":0.2421366867411865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}