{"id":"W2168856897","doi":"10.1534/g3.114.011205","title":"Conditional Genetic Interactions of<i>RTT107</i>,<i>SLX4</i>, and<i>HRQ1</i>Reveal Dynamic Networks upon DNA Damage in<i>S. cerevisiae</i>","year":2014,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"RecQ helicase; Genetics; Saccharomyces cerevisiae; Gene; Biology; DNA damage; Genetic screen; Epistasis; DNA; Computational biology; Phenotype; Genome instability","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007398023,0.0004096198,0.0002241108,0.0003051589,0.0001481152,0.0003089333,0.0002823822,0.0002394886,0.001316927],"category_scores_gemma":[0.00008609124,0.0002417958,0.0003829813,0.0002120305,0.0002647318,0.0001485518,0.0003361449,0.0006655253,0.0003408155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004701344,"about_ca_system_score_gemma":0.0002183994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001980285,"about_ca_topic_score_gemma":0.002695776,"domain_scores_codex":[0.9998584,0.00001178958,0.00001251741,0.00005286055,0.0000362193,0.00002821418],"domain_scores_gemma":[0.9998186,0.00002621438,0.00007787967,0.00002233892,0.00001013857,0.00004491488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003713202,0.000007015356,0.0002268185,0.00001085796,0.000005195274,0.00003677534,0.000008457544,0.00007807153,0.9990723,0.00005087683,0.00001997798,0.000446493],"study_design_scores_gemma":[0.000009257252,0.00006618362,0.01045909,0.000004314368,0.00002297206,0.0001777966,0.0000448766,0.001673661,0.9859415,0.00006012133,0.001531654,0.000008587554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927623,0.0003308879,0.00441926,0.00008023257,0.00001966975,0.00002098604,0.001133922,0.0002930405,0.0009397454],"genre_scores_gemma":[0.9910815,0.000255835,0.004193076,0.00008152521,0.000004442908,0.00004446522,0.001805657,0.0001397393,0.002393623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980285,"threshold_uncertainty_score":0.004405558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005266608345923199,"score_gpt":0.2316695968959354,"score_spread":0.2264029885500122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}