{"id":"W2168858265","doi":"10.1210/en.2009-0454","title":"Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; University of Texas Southwestern Medical Center","keywords":"Proopiomelanocortin; Glucose homeostasis; Internal medicine; Endocrinology; Energy homeostasis; Leptin; Homeostasis; Adipose tissue; Insulin resistance; Biology; P110α; Insulin receptor; Insulin; PI3K/AKT/mTOR pathway; Signal transduction; Hypothalamus; Cell biology; Medicine; Obesity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005938367,0.0002578131,0.0001421139,0.0001843367,0.0001343695,0.0003166584,0.0001440486,0.0001605495,0.0004431656],"category_scores_gemma":[0.00009500654,0.0001012409,0.00009807022,0.0001125594,0.0002467494,0.0001806567,0.000193697,0.0004271301,0.0002031486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003306514,"about_ca_system_score_gemma":0.0002175784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005679571,"about_ca_topic_score_gemma":0.0009743386,"domain_scores_codex":[0.9999642,0.000003353601,0.000002192317,0.000007862844,0.00001280191,0.000009664999],"domain_scores_gemma":[0.9999731,0.000002165167,0.000007610378,0.000002457896,0.000003637621,0.00001096024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002784956,0.00002886823,0.001344993,0.00004850526,0.000007881883,0.0002358898,0.00001739814,0.0001678393,0.9853696,0.0003647955,0.000102105,0.01203374],"study_design_scores_gemma":[0.00006255825,0.0004031833,0.07895132,0.00002804472,0.00007892071,0.00151895,0.0001197051,0.002994259,0.9041578,0.002927149,0.008740719,0.00001740686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885217,0.005705747,0.003059085,0.0002410374,0.00004191975,0.000009514659,0.0001020901,0.000058331,0.002260493],"genre_scores_gemma":[0.9913027,0.004946545,0.001951775,0.00006246494,0.000019302,0.000009353558,0.0001310834,0.00001301499,0.001563702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005679571,"threshold_uncertainty_score":0.002399087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997555477840755,"score_gpt":0.2638632437199204,"score_spread":0.2438876889415128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}