{"id":"W2168882302","doi":"10.1021/bp060089y","title":"Dynamic Metabolic Modeling for a MAB Bioprocess","year":2007,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Bioprocess; Biochemical engineering; Monoclonal antibody; Metabolic flux analysis; Bioprocess engineering; Computer science; Biological system; Flux balance analysis; Key (lock); Computational biology; Metabolic network; Systems biology; Chemistry; Biology; Metabolism; Biochemistry; Engineering; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134657,0.0001919359,0.0001703544,0.0001373787,0.0001764858,0.00002264954,0.0003003079,0.0005701122,0.000008157846],"category_scores_gemma":[0.00006485977,0.0001756971,0.0001334077,0.0001736179,0.0001746899,0.000004280426,0.0001511976,0.0001028851,0.000006891456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079457,"about_ca_system_score_gemma":0.00004398929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005100603,"about_ca_topic_score_gemma":0.00002464323,"domain_scores_codex":[0.9987244,0.0000106841,0.000235266,0.0004810011,0.00008642965,0.0004621913],"domain_scores_gemma":[0.99931,0.000005689045,0.00008727256,0.0004060676,0.0001086027,0.00008237747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006264698,0.0003774169,0.001690114,0.0001147958,0.0002221421,0.0000113462,0.00002680717,0.0002704436,0.896318,0.005189326,0.0009068551,0.09424632],"study_design_scores_gemma":[0.001493699,0.0007372877,0.0002498412,0.00003227176,0.00006956692,0.00006749671,0.0001353385,0.009745934,0.9300114,0.002726613,0.05415925,0.0005713322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9024532,0.01107723,0.08501229,0.0003718669,0.0003348541,0.000462518,0.00003077828,0.0001610552,0.00009616657],"genre_scores_gemma":[0.9927163,0.0002938684,0.00630679,0.0001692502,0.0001234909,0.0001499237,0.00007755616,0.00003719732,0.0001256951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09367499,"threshold_uncertainty_score":0.716472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009158610485061437,"score_gpt":0.2946332403517494,"score_spread":0.285474629866688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}