{"id":"W2168882302","doi":"10.1021/bp060089y","title":"Dynamic Metabolic Modeling for a MAB Bioprocess","year":2007,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Bioprocess; Biochemical engineering; Monoclonal antibody; Metabolic flux analysis; Bioprocess engineering; Computer science; Biological system; Flux balance analysis; Key (lock); Computational biology; Metabolic network; Systems biology; Chemistry; Biology; Metabolism; Biochemistry; Engineering; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003995792,0.0007616621,0.00068342,0.0003765153,0.0003455348,0.001019019,0.0007619373,0.0009836771,0.002095859],"category_scores_gemma":[0.0007346796,0.0004327394,0.0009271866,0.0005239455,0.000444681,0.0006618529,0.0005861944,0.0007553948,0.0003559123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008481272,"about_ca_system_score_gemma":0.000923929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01092393,"about_ca_topic_score_gemma":0.004731388,"domain_scores_codex":[0.9998391,0.00004531744,0.000007973916,0.00004997381,0.00003963377,0.00001798047],"domain_scores_gemma":[0.9998184,0.0001026479,0.00002526211,0.000009873235,0.00003477985,0.000009106725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00002231422,0.00001402314,0.0001525936,0.00004052118,0.000009705032,0.00003173956,0.00001630971,0.9871964,0.003430536,0.006333146,0.0001109388,0.002641731],"study_design_scores_gemma":[0.000002146542,0.000005819007,0.00004753914,0.000001026506,0.000002793348,0.000003328083,0.000001763398,0.998571,0.0002301562,0.0008723247,0.0002603302,0.000001733295],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05038207,0.0006505809,0.9361535,0.0004856517,0.00005732237,0.00007271465,0.0004580282,0.0002361324,0.01150414],"genre_scores_gemma":[0.891614,0.001638563,0.08706629,0.0001182797,0.00004151779,0.0006565783,0.0007583417,0.0001020526,0.0180044],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01092393,"threshold_uncertainty_score":0.02172065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009158610485061437,"score_gpt":0.2946332403517494,"score_spread":0.285474629866688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}