{"id":"W2168891695","doi":"10.1177/0192623311419524","title":"A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat","year":2011,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Apotex (Canada)","funders":"","keywords":"Cardiotoxicity; Medicine; Internal medicine; Vacuolization; Endocrinology; Myocyte; Myofibril; Apoptosis; Necrosis; Toxicity; Lactate dehydrogenase; Heart failure; Endoplasmic reticulum; Cardiac myocyte; Pharmacology; Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002164378,0.0001512522,0.0004317315,0.0001187686,0.00003255921,0.000001853401,0.0001629965,0.0002346504,0.0005039123],"category_scores_gemma":[0.0008150442,0.00009564773,0.00009700879,0.000211922,0.0001287321,0.00003377094,0.00004661836,0.0002506419,0.00006111772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342922,"about_ca_system_score_gemma":0.000274014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000652022,"about_ca_topic_score_gemma":0.0000530747,"domain_scores_codex":[0.9977663,0.0009573087,0.0003722636,0.0002800885,0.0003485242,0.0002755291],"domain_scores_gemma":[0.9990087,0.000154653,0.0001644655,0.0005109393,0.0001208785,0.00004034058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007508476,0.003181854,0.1887673,0.0001170576,0.0001782186,0.001257541,0.02225595,0.00004209709,0.7427064,0.0004233931,0.0002720905,0.04004719],"study_design_scores_gemma":[0.008289905,0.001748514,0.8884652,0.00003248506,0.0003471994,0.0006333222,0.0008011601,0.001423701,0.09752607,0.0005831395,0.00002074427,0.0001285249],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987699,0.000178591,0.00001866293,0.0001119115,0.0001508897,0.001444638,0.000004473946,0.00003345248,0.01035837],"genre_scores_gemma":[0.9980376,0.00001651466,0.001257113,0.0003412048,0.00002779694,0.0002689733,0.00001422137,0.000009054257,0.00002750013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6996979,"threshold_uncertainty_score":0.5517486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1823506053084049,"score_gpt":0.3586507319419527,"score_spread":0.1763001266335479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}