{"id":"W2168933209","doi":"10.1128/jb.01415-07","title":"Diversity, Activity, and Evolution of CRISPR Loci in <i>Streptococcus thermophilus</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":795,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Biology; Genetics; Streptococcus thermophilus; Trans-activating crRNA; Locus (genetics); Mobile genetic elements; CRISPR interference; Plasmid; Bacteriophage; Gene; Computational biology; Palindrome; Cas9; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368791,0.0002778881,0.000255843,0.0008247918,0.0002315541,0.0004192175,0.0001495418,0.0002799997,0.0002946861],"category_scores_gemma":[0.0005350696,0.0001926922,0.0003872566,0.000807244,0.0002122762,0.0001587332,0.0003186769,0.0002877182,0.0001452116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694892,"about_ca_system_score_gemma":0.000280452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261684,"about_ca_topic_score_gemma":0.00142882,"domain_scores_codex":[0.9996201,0.00006400612,0.00005896188,0.00007960139,0.0001166695,0.00006069874],"domain_scores_gemma":[0.9995632,0.00007094048,0.0001948683,0.00004492443,0.00006142046,0.00006477439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002147232,0.00004647299,0.04371877,0.00005773747,0.00004801216,0.0001215806,0.0002196941,0.0006321989,0.9491726,0.0001026653,0.00003470761,0.00563083],"study_design_scores_gemma":[0.00001388978,0.0005237329,0.7073977,0.00003219744,0.0001312479,0.001677055,0.0004807625,0.003605426,0.2844061,0.0002945596,0.001391138,0.0000461083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990098,0.0001112995,0.0003688587,0.00001133428,0.000001244402,0.000005169404,0.0002315144,0.00001064322,0.0002501158],"genre_scores_gemma":[0.9982904,0.0000670485,0.0008437473,0.00001126188,0.000001558138,0.000009719352,0.0005773918,0.000007128727,0.0001916676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261684,"threshold_uncertainty_score":0.002508759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672331108099971,"score_gpt":0.2689947885452944,"score_spread":0.2622714774642947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}