{"id":"W2168933209","doi":"10.1128/jb.01415-07","title":"Diversity, Activity, and Evolution of CRISPR Loci in <i>Streptococcus thermophilus</i>","year":2007,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":795,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Biology; Genetics; Streptococcus thermophilus; Trans-activating crRNA; Locus (genetics); Mobile genetic elements; CRISPR interference; Plasmid; Bacteriophage; Gene; Computational biology; Palindrome; Cas9; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003283158,0.00006912558,0.0001632111,0.00009455521,0.00002793531,0.00000189627,0.00009256154,0.0001128797,0.000004860869],"category_scores_gemma":[0.0000381121,0.00006349137,0.00005192786,0.00004856164,0.00006022284,0.000004273882,0.0002365907,0.00009755645,1.850794e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000191479,"about_ca_system_score_gemma":0.00002510591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003277041,"about_ca_topic_score_gemma":0.00006104663,"domain_scores_codex":[0.999501,0.00002824395,0.0002094901,0.00008530002,0.00005266075,0.0001232971],"domain_scores_gemma":[0.9996548,0.00001732404,0.0001447513,0.00008129923,0.00005818835,0.00004358788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001462365,0.00002935882,0.1754543,0.00001150416,0.00002118019,0.000008581008,0.00007421935,0.00006172482,0.8224652,0.0000119622,0.00002536116,0.001690281],"study_design_scores_gemma":[0.0004907752,0.0003602018,0.7787678,0.0000105073,0.00001041034,0.000087664,0.00006266208,0.000008333637,0.219749,0.00007551528,0.0003195027,0.00005760061],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886152,0.0006540197,0.01040388,0.00004851176,0.0001189892,0.00004182837,0.000001868254,0.000001002091,0.0001146683],"genre_scores_gemma":[0.9995267,0.0001518035,0.0001735846,0.00001755889,0.0001134497,2.248831e-7,9.973941e-7,0.00000492487,0.00001079534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6033135,"threshold_uncertainty_score":0.2589103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672331108099971,"score_gpt":0.2689947885452944,"score_spread":0.2622714774642947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}