{"id":"W2168949615","doi":"10.4049/jimmunol.172.9.5154","title":"Cutting Edge: IL-21 Is a Switch Factor for the Production of IgG1 and IgG3 by Human B Cells","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"CD19; CD40; Cytidine deaminase; Immunoglobulin class switching; Molecular biology; Biology; Stimulation; Antibody; B cell; Cytokine; Cell biology; Immunology; Cytotoxic T cell; In vitro; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570562,0.0004832748,0.000177539,0.0002405397,0.0002054143,0.0007105462,0.0001395944,0.0004810232,0.005833108],"category_scores_gemma":[0.0002425946,0.0001506711,0.0002534788,0.0001523001,0.0002227113,0.0002244947,0.0002443877,0.0005014213,0.002800693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979529,"about_ca_system_score_gemma":0.000215996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001685728,"about_ca_topic_score_gemma":0.0002293263,"domain_scores_codex":[0.9998273,0.00002462297,0.00001868811,0.0000353404,0.00005930625,0.00003472024],"domain_scores_gemma":[0.9998487,0.00004646328,0.00002693659,0.00001763133,0.00002900997,0.00003127168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003471798,0.00004506435,0.001043775,0.0003260667,0.00001302707,0.0003397837,0.00003563401,0.0001060455,0.9610795,0.00111859,0.00204985,0.03349544],"study_design_scores_gemma":[0.00004804444,0.0003672155,0.007445925,0.00004741488,0.00004455919,0.001827835,0.00004677505,0.0005839777,0.9469625,0.0007110398,0.04190712,0.000007550616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.887771,0.05011946,0.01537994,0.003625967,0.001713592,0.0001416364,0.001429752,0.00065369,0.03916502],"genre_scores_gemma":[0.9639646,0.01041384,0.006000823,0.001146157,0.0006831755,0.00004309056,0.001651676,0.00005682115,0.01603976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005833108,"threshold_uncertainty_score":0.01951373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345073025559106,"score_gpt":0.2454503283515752,"score_spread":0.2319995980959842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}