{"id":"W2168956077","doi":"10.1093/jac/dkl022","title":"Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis","year":2006,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Astellas Pharma; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Echinocandin; Micafungin; Anidulafungin; Caspofungin; Candida albicans; Biology; Microbiology; Candida glabrata; Daptomycin; Candida dubliniensis; Multilocus sequence typing; Corpus albicans; Medicine; Antifungal; Genotype; Staphylococcus aureus; Amphotericin B; Gene; Fluconazole; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002025548,0.000201967,0.0003566374,0.0002265633,0.000259492,0.0003235753,0.0001820195,0.0003834054,0.0007951697],"category_scores_gemma":[0.001047818,0.000102096,0.0002079243,0.0002511595,0.000217329,0.0002496616,0.000179314,0.0005471723,0.0001797664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002591044,"about_ca_system_score_gemma":0.0001489498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367907,"about_ca_topic_score_gemma":0.0007721371,"domain_scores_codex":[0.9998301,0.0000212577,0.00002507303,0.00003084041,0.00004900847,0.00004376377],"domain_scores_gemma":[0.9995022,0.0001496567,0.000167214,0.00004096443,0.0000451,0.00009483928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003725747,0.000359205,0.4061746,0.0003614255,0.0002003378,0.09653613,0.001334685,0.0004993687,0.4112523,0.0001426,0.0004953064,0.07891829],"study_design_scores_gemma":[0.00006438574,0.004124948,0.6835082,0.00003918974,0.0001859382,0.234942,0.0003504848,0.0007736121,0.07295787,0.00006624345,0.002967632,0.00001965659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980322,0.001152796,0.0002547847,0.00005621167,0.000004289124,0.000009444379,0.00004044831,0.000009334063,0.0004405611],"genre_scores_gemma":[0.9994234,0.0001970628,0.0001132363,0.00003717465,0.000008827565,0.000002705181,0.00007116691,0.000001926679,0.0001444751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007951697,"threshold_uncertainty_score":0.002660036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649117425673411,"score_gpt":0.294192570947383,"score_spread":0.2777013966906489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}