{"id":"W2168956077","doi":"10.1093/jac/dkl022","title":"Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis","year":2006,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Astellas Pharma; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Echinocandin; Micafungin; Anidulafungin; Caspofungin; Candida albicans; Biology; Microbiology; Candida glabrata; Daptomycin; Candida dubliniensis; Multilocus sequence typing; Corpus albicans; Medicine; Antifungal; Genotype; Staphylococcus aureus; Amphotericin B; Gene; Fluconazole; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957921,0.0001889853,0.0008833905,0.0001198884,0.00005098775,0.00001448786,0.00008221738,0.0001122678,0.00002975377],"category_scores_gemma":[0.00004556737,0.0001379963,0.0006886976,0.0001423013,0.0001474905,0.0001635493,0.000005078316,0.00008043923,1.832027e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760288,"about_ca_system_score_gemma":0.0003366759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002878681,"about_ca_topic_score_gemma":0.0001015408,"domain_scores_codex":[0.9987418,0.00003036983,0.0005928315,0.0001680287,0.0002362757,0.0002307109],"domain_scores_gemma":[0.9985538,0.0001142996,0.0007517686,0.0001934196,0.0003139585,0.00007271266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007484402,0.001695236,0.3328319,0.0001501383,0.0004386186,0.0001193375,0.0002880832,0.000005553175,0.6532056,0.000008562767,0.0005737948,0.00319874],"study_design_scores_gemma":[0.008465501,0.002577253,0.2055294,0.0002952423,0.0002387733,0.0001103564,0.00002784282,0.00001271126,0.7820749,0.00004089109,0.0005154677,0.0001116076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976809,0.000313435,0.0005318847,0.0005954969,0.0001207339,0.0006488048,0.00006659691,0.000006990558,0.0000351283],"genre_scores_gemma":[0.9959442,0.0001623163,0.003372728,0.00005882191,0.0001775681,0.000003135193,0.000007935299,0.00002686807,0.000246427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1288694,"threshold_uncertainty_score":0.5627326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649117425673411,"score_gpt":0.294192570947383,"score_spread":0.2777013966906489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}