{"id":"W2168969562","doi":"10.3109/1547691x.2012.724730","title":"A novel T<sub>H</sub>17-type cell is rapidly increased in the liver in response to acetaminophen-induced liver injury: T<sub>H</sub>17 cells and the innate immune response","year":2012,"lang":"en","type":"article","venue":"Journal of Immunotoxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Immune system; Acetaminophen; Liver injury; Acquired immune system; Innate immune system; Immunology; Natural killer T cell; Cytokine; Interleukin 12; Interleukin 21; T cell; Biology; Cytotoxic T cell; Medicine; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.02391315,0.0006417159,0.001094448,0.001183612,0.0005539114,0.00009105644,0.001080413,0.001235896,0.0001114802],"category_scores_gemma":[0.001519839,0.0004751233,0.0003337355,0.001419877,0.0005748682,0.0005130465,0.0004061099,0.004354737,0.0001492357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005027838,"about_ca_system_score_gemma":0.0006054888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001155482,"about_ca_topic_score_gemma":0.00009061219,"domain_scores_codex":[0.9838879,0.0121401,0.001712033,0.0004750057,0.0005034743,0.00128149],"domain_scores_gemma":[0.9920639,0.005446107,0.001135126,0.0006308556,0.000354592,0.0003693679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1084897,0.001430599,0.0004136656,0.00003723068,0.0001817989,0.0001742562,0.01304295,0.0001309451,0.870551,0.00002862693,0.001441777,0.004077489],"study_design_scores_gemma":[0.01157926,0.00216836,0.06815766,0.00008282459,0.0002152739,0.0007287243,0.0008596802,0.0003971239,0.9040739,0.00006309855,0.01115766,0.000516432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893669,0.002587649,0.00005564225,0.003689235,0.001957446,0.002162194,0.00004238449,0.00002601324,0.0001125682],"genre_scores_gemma":[0.9858825,0.002056294,0.0001076862,0.01126651,0.0003791992,0.0001647436,0.000003231826,0.00006732554,0.00007249559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09691041,"threshold_uncertainty_score":0.99977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05805227198676585,"score_gpt":0.3417694541452959,"score_spread":0.28371718215853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}