{"id":"W2169024245","doi":"10.1210/en.2003-0266","title":"Nuclear Factor-κB Translocation Mediates Double-Stranded Ribonucleic Acid-Induced NIT-1 β-Cell Apoptosis and Up-Regulates Caspase-12 and Tumor Necrosis Factor Receptor-Associated Ligand (TRAIL)","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; University of British Columbia","funders":"","keywords":"Molecular biology; Biology; Apoptosis; TUNEL assay; Transfection; Fas ligand; Caspase; Caspase 8; Terminal deoxynucleotidyl transferase; Caspase 3; Programmed cell death; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006330346,0.0003484472,0.0003453689,0.000109275,0.000221448,0.00007467612,0.0001296486,0.0002588587,0.0002069565],"category_scores_gemma":[0.00009896824,0.0003451683,0.0001035749,0.0001095163,0.0001913756,0.00002304289,0.00004311123,0.0001529282,0.00001418828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002857974,"about_ca_system_score_gemma":0.00007372609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000658618,"about_ca_topic_score_gemma":0.00007772772,"domain_scores_codex":[0.998218,0.0001479799,0.0003501973,0.0006144082,0.0001442349,0.00052519],"domain_scores_gemma":[0.9991395,0.00003688103,0.0001572262,0.0002854054,0.00009140636,0.0002895236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002548865,0.0001255598,0.006874903,0.00002970545,0.00009210338,0.000002784223,0.000326526,0.000001832277,0.990536,0.0001298965,0.0002733547,0.001352446],"study_design_scores_gemma":[0.005233831,0.0002908162,0.01113709,0.0000115053,0.00005475926,0.00002332868,0.0002579864,0.00002431327,0.9805732,0.00006186153,0.001923129,0.0004081767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979439,0.0006894792,0.00001777038,0.0003288216,0.0002616095,0.0003468642,0.00009586567,0.00006987255,0.0002458682],"genre_scores_gemma":[0.9983466,0.0006294771,0.0001107185,0.0002010425,0.00005032121,0.00002717732,0.0001699422,0.00005382461,0.0004108679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009962802,"threshold_uncertainty_score":0.9999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632097557844608,"score_gpt":0.2347562628331752,"score_spread":0.2184352872547291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}