{"id":"W2169024245","doi":"10.1210/en.2003-0266","title":"Nuclear Factor-κB Translocation Mediates Double-Stranded Ribonucleic Acid-Induced NIT-1 β-Cell Apoptosis and Up-Regulates Caspase-12 and Tumor Necrosis Factor Receptor-Associated Ligand (TRAIL)","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; University of British Columbia","funders":"","keywords":"Molecular biology; Biology; Apoptosis; TUNEL assay; Transfection; Fas ligand; Caspase; Caspase 8; Terminal deoxynucleotidyl transferase; Caspase 3; Programmed cell death; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080721,0.0004237403,0.0002021651,0.0002265158,0.000162866,0.0002542075,0.0001021754,0.0001519232,0.00142506],"category_scores_gemma":[0.00008964941,0.0001481467,0.0002776133,0.0001529205,0.0002078857,0.0001789435,0.0001387128,0.0004496122,0.0005114597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196256,"about_ca_system_score_gemma":0.0001882639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002597884,"about_ca_topic_score_gemma":0.0004086806,"domain_scores_codex":[0.9998807,0.00001229655,0.00001096848,0.00002592651,0.0000403123,0.00002989483],"domain_scores_gemma":[0.9999142,0.000007578252,0.00003327094,0.000007436872,0.00001444926,0.00002312172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008864563,0.00001561402,0.0001758986,0.00005245587,0.000003094166,0.00006392369,0.00002054102,0.00001328518,0.9986174,0.00004789855,0.00001462036,0.0008865527],"study_design_scores_gemma":[0.00003760355,0.000395835,0.005810186,0.00002021308,0.00002571274,0.0007135829,0.00007441493,0.0004635169,0.9876766,0.00007550523,0.004702435,0.000004416052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861892,0.005371149,0.005070118,0.00008428639,0.0000664387,0.00004071588,0.0002843993,0.0001057582,0.002788004],"genre_scores_gemma":[0.990555,0.003205462,0.001985445,0.0000375318,0.00001931456,0.00004343373,0.000556133,0.00001229365,0.003585252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142506,"threshold_uncertainty_score":0.004767299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632097557844608,"score_gpt":0.2347562628331752,"score_spread":0.2184352872547291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}