{"id":"W2169032670","doi":"10.1111/j.1365-2958.2005.04795.x","title":"VSG switching in <i>Trypanosoma brucei</i>: antigenic variation analysed using RNAi in the absence of immune selection","year":2005,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Biology; Trypanosoma brucei; Antigenic variation; RNA interference; Negative selection; Genetics; Cell biology; Gene; Antigen; Glycoprotein; Computational biology; Genome; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008565973,0.0001088599,0.0002491578,0.0003370433,0.0000516043,0.00001080905,0.0001683421,0.0001224099,0.00004052365],"category_scores_gemma":[0.0001299436,0.00008855869,0.0000905694,0.0008730387,0.00005986287,0.00006445208,0.0000387619,0.0002991207,0.00001022656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299483,"about_ca_system_score_gemma":0.0001325364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005414559,"about_ca_topic_score_gemma":0.0002630192,"domain_scores_codex":[0.9987267,0.0002133633,0.0004395128,0.0002354447,0.00008191852,0.0003030738],"domain_scores_gemma":[0.999427,0.00005592617,0.000123919,0.0002824515,0.00008148443,0.00002917304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005517682,0.0001440503,0.004262276,0.00001444851,0.00002708832,0.00001043335,0.00033613,0.0003439356,0.9936893,0.000299836,0.00001440093,0.0008029004],"study_design_scores_gemma":[0.001208595,0.0001281342,0.5150262,0.00004900993,0.00002097082,0.000359427,0.00009299611,0.002600285,0.4796333,0.00007585366,0.0007024063,0.000102857],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890718,0.0007321597,0.008519834,0.00105462,0.00002373729,0.0003707329,0.000004898829,0.0000112207,0.0002110023],"genre_scores_gemma":[0.9968265,0.00005049843,0.00264555,0.0003691055,0.00003433807,0.00001135724,0.00003637948,0.00001106954,0.00001522436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.514056,"threshold_uncertainty_score":0.3611318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512192454924588,"score_gpt":0.3033707931711979,"score_spread":0.288248868621952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}