{"id":"W2169034640","doi":"10.3899/jrheum.140692","title":"Powered for Success: Considerations for Using the Candidate Gene Approach in Rheumatic Diseases in the Post-genomics Era","year":2014,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Genome-wide association study; International HapMap Project; Linkage disequilibrium; Candidate gene; Genetic association; Genetics; Single-nucleotide polymorphism; 1000 Genomes Project; Minor allele frequency; Biology; Genomics; Genotyping; Gene; Medicine; Computational biology; Genome; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3947256,0.002224078,0.007893743,0.006606234,0.004575206,0.01638715,0.008407426,0.01606854,0.01622945],"category_scores_gemma":[0.565756,0.001246926,0.002709758,0.004171088,0.02921878,0.02430924,0.01327098,0.02233928,0.005563729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00538502,"about_ca_system_score_gemma":0.01304315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00390981,"about_ca_topic_score_gemma":0.004835014,"domain_scores_codex":[0.7973439,0.155083,0.007723715,0.006456674,0.0315512,0.001841609],"domain_scores_gemma":[0.2684119,0.675728,0.006481237,0.01333078,0.02933467,0.006713459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001756404,0.0003176792,0.0183769,0.004145349,0.0009941653,0.001482141,0.00343685,0.001782762,0.0005343199,0.2154321,0.1899604,0.5617809],"study_design_scores_gemma":[0.0008146123,0.001958779,0.01466149,0.01587181,0.0007703229,0.004052907,0.003588036,0.006085971,0.0005675216,0.662112,0.2889521,0.0005644829],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003936409,0.100561,0.0674611,0.793323,0.01337874,0.0006000391,0.0003282705,0.0003990823,0.02001231],"genre_scores_gemma":[0.2008668,0.09902813,0.2025887,0.4128393,0.06903972,0.005314512,0.0003426305,0.001436756,0.008543397],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3947256,"threshold_uncertainty_score":0.7464111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03444168422735159,"score_gpt":0.2893840147636472,"score_spread":0.2549423305362956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}