{"id":"W2169104034","doi":"10.1128/iai.00718-12","title":"Involvement of Signal Regulatory Protein α, a Negative Regulator of Toll-Like Receptor Signaling, in Impairing the MyD88-Independent Pathway and Intracellular Killing of Burkholderia pseudomallei-Infected Mouse Macrophages","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Thailand Research Fund; University of Calgary","keywords":"Burkholderia pseudomallei; Biology; Downregulation and upregulation; Signal transduction; Intracellular parasite; Intracellular; Innate immune system; Microbiology; Cell biology; Toll-like receptor; Melioidosis; Immune system; Immunology; Gene; Bacteria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769592,0.0005421865,0.0003480213,0.0001950994,0.0001245334,0.0001756663,0.0002018409,0.0004016066,0.0004291398],"category_scores_gemma":[0.0001622214,0.0001906342,0.0002560435,0.0001119269,0.0002807875,0.0002553923,0.0001432033,0.0005154411,0.0002504426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001186141,"about_ca_system_score_gemma":0.0001539314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621229,"about_ca_topic_score_gemma":0.0001422534,"domain_scores_codex":[0.9997997,0.00006097935,0.00002788762,0.0000295089,0.00003259982,0.00004925972],"domain_scores_gemma":[0.9998832,0.00001616278,0.0000378643,0.00001645455,0.0000113957,0.00003489114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003694189,0.00004797186,0.00008817126,0.00004158823,0.000003519693,0.00005200527,0.00001110092,0.00003024823,0.9988943,0.00003115091,0.000009097059,0.0004214581],"study_design_scores_gemma":[0.0001149989,0.00141242,0.005776288,0.00001009708,0.00003953405,0.0004582274,0.00004048467,0.001307831,0.9895075,0.0000727366,0.001253452,0.000006448916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952143,0.002202485,0.001639547,0.00009482879,0.00003659282,0.00003303976,0.00010851,0.00004427208,0.0006264613],"genre_scores_gemma":[0.9960247,0.001355919,0.001273917,0.00006744119,0.00001841986,0.0000624229,0.0002041828,0.000007860743,0.0009850306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005421865,"threshold_uncertainty_score":0.001464665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642196573073921,"score_gpt":0.2371646236088103,"score_spread":0.2207426578780711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}