{"id":"W2169107624","doi":"10.1084/jem.20062032","title":"Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation","year":2007,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Somatic hypermutation; Somatic cell; Chromatin; Biology; Genetics; DNA; Mutation; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133869,0.0001445723,0.0001356212,0.0005143476,0.0001249043,0.0002471209,0.0001347203,0.0003008804,0.001352023],"category_scores_gemma":[0.0002261168,0.0001596505,0.0001167266,0.0001844309,0.0001843084,0.0001519242,0.0001753577,0.0001616196,0.0002487288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009609087,"about_ca_system_score_gemma":0.00007138211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002584851,"about_ca_topic_score_gemma":0.0003955821,"domain_scores_codex":[0.9999144,0.00001230189,0.000005155122,0.00003417209,0.00001788118,0.00001610572],"domain_scores_gemma":[0.9998488,0.00004823549,0.00003080901,0.00001400326,0.0000222354,0.00003581598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002827452,0.000003417642,0.00219273,0.00001696406,0.00000404941,0.00005959481,0.00002015049,0.00001057641,0.9968308,0.00004549968,0.000005099697,0.0007829075],"study_design_scores_gemma":[0.00001156488,0.0002617507,0.08862796,0.00001011456,0.00002936907,0.001800012,0.0001135347,0.0006637185,0.9069289,0.0002283722,0.001319741,0.000004937226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932652,0.001513973,0.004147041,0.00002461313,0.000007034989,0.000009724065,0.0001030679,0.00004275387,0.0008867306],"genre_scores_gemma":[0.9973233,0.0003063233,0.001780232,0.00002270003,0.000005736413,0.000006937718,0.0001440359,0.000004415479,0.0004063527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352023,"threshold_uncertainty_score":0.00452292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765924755880025,"score_gpt":0.283338607132676,"score_spread":0.2656793595738757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}