{"id":"W2169118391","doi":"10.1210/en.2007-1557","title":"Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Beta cell; Insulin; Internal medicine; Endocrinology; Cell growth; Islet; Biology; Somatostatin; Insulin receptor; Kinase; Protein kinase B; Signal transduction; Cell biology; Insulin resistance; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003223945,0.0001262564,0.0002731659,0.0001313131,0.00009235999,0.000003614421,0.00004379056,0.0000730269,0.0005334545],"category_scores_gemma":[0.0001100725,0.0001093601,0.00005772889,0.0001168593,0.0001043175,0.0000553851,0.00002938347,0.0001685322,0.0006416361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005045097,"about_ca_system_score_gemma":0.0000979976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002084971,"about_ca_topic_score_gemma":6.409247e-7,"domain_scores_codex":[0.9991028,0.00004641264,0.0002125347,0.0002220709,0.000120099,0.000296036],"domain_scores_gemma":[0.9994631,0.00008891364,0.00004913389,0.0002262333,0.00006872667,0.000103855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001730716,0.002069991,0.5308712,0.0003484413,0.000205259,0.00190958,0.0009827013,0.0001306266,0.3969823,0.0008487965,0.03596383,0.02795651],"study_design_scores_gemma":[0.01768489,0.002265898,0.4362045,0.00004517164,0.00021929,0.002448764,0.00007981165,0.002499982,0.451546,0.0005884793,0.08585798,0.0005593318],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972362,0.00115629,0.0005281411,0.0007828859,0.0002631986,0.00028267,0.000002328061,0.000179485,0.02444297],"genre_scores_gemma":[0.989366,0.000195511,0.001312738,0.002233782,0.000219306,0.00003637885,0.00007606513,0.00001587733,0.006544348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09466678,"threshold_uncertainty_score":0.8247148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823432390664999,"score_gpt":0.2428689416544296,"score_spread":0.2246346177477796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}