{"id":"W2169119507","doi":"10.1371/journal.pgen.1004543","title":"Roles of Type 1A Topoisomerases in Genome Maintenance in Escherichia coli","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; DNA supercoil; Nucleoid; RecQ helicase; Chromosome segregation; Genetics; DNA replication; Mutant; Topoisomerase; Helicase; Genome; Overproduction; Homologous recombination; Genome instability; Holliday junction; DNA; Mutation; Wild type; Cell biology; Escherichia coli; Chromosome; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820275,0.0005236007,0.0002946805,0.0006272087,0.0003491066,0.001082944,0.0002892262,0.000443844,0.0002501283],"category_scores_gemma":[0.000258933,0.0002851341,0.0002192904,0.0002874695,0.0002945516,0.000312806,0.0003205738,0.000435572,0.0003415478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005877754,"about_ca_system_score_gemma":0.0003699762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617913,"about_ca_topic_score_gemma":0.001186783,"domain_scores_codex":[0.9997959,0.00003687181,0.00002663442,0.00004220433,0.00007096843,0.0000275633],"domain_scores_gemma":[0.9997398,0.00003638578,0.00009285128,0.00003153034,0.00003489206,0.00006449229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093342,0.00003069985,0.002317194,0.00006861272,0.000007232445,0.0001307942,0.00002808496,0.0001859544,0.9917807,0.0002816815,0.00005093907,0.005008744],"study_design_scores_gemma":[0.00002554003,0.000354512,0.05470305,0.0000498933,0.00006827935,0.001560906,0.0002142942,0.002318599,0.9341302,0.000606053,0.005925371,0.00004333354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740291,0.01726497,0.005734231,0.000249669,0.00005092051,0.00002236394,0.0003828666,0.0001998919,0.002066042],"genre_scores_gemma":[0.9918742,0.003440822,0.003327464,0.00005634081,0.000009785337,0.00001165545,0.0003064466,0.00001340897,0.0009598365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617913,"threshold_uncertainty_score":0.004264653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316834685014746,"score_gpt":0.2340900447079196,"score_spread":0.2209216978577721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}