{"id":"W2169119507","doi":"10.1371/journal.pgen.1004543","title":"Roles of Type 1A Topoisomerases in Genome Maintenance in Escherichia coli","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; DNA supercoil; Nucleoid; RecQ helicase; Chromosome segregation; Genetics; DNA replication; Mutant; Topoisomerase; Helicase; Genome; Overproduction; Homologous recombination; Genome instability; Holliday junction; DNA; Mutation; Wild type; Cell biology; Escherichia coli; Chromosome; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009981174,0.0001066996,0.0001597889,0.00004811497,0.00001092119,0.000006244392,0.0001567393,0.00009461334,0.00001485019],"category_scores_gemma":[0.00002517794,0.0001091531,0.0000320721,0.0001257838,0.00003756463,0.000001117175,0.00006369894,0.00006228843,0.000003516784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000151582,"about_ca_system_score_gemma":0.0000504746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001172252,"about_ca_topic_score_gemma":0.0004591228,"domain_scores_codex":[0.9992623,0.00003785504,0.000207475,0.0002044821,0.00008586588,0.0002020399],"domain_scores_gemma":[0.999581,0.000008035273,0.0000604862,0.0002556297,0.0000564645,0.00003841997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007225831,0.0000978741,0.001758674,0.00002122997,0.00001423484,8.709092e-7,0.00007588838,0.0005134469,0.9961764,0.000250292,0.00001277005,0.001006014],"study_design_scores_gemma":[0.0006873156,0.0005443433,0.003176625,0.0000285481,0.00001110225,9.672501e-7,0.00007264884,0.001797546,0.9715138,0.0006110814,0.02136816,0.0001878809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997137,0.001802827,0.000224581,0.00005601532,0.00007822969,0.0001280014,0.000009252993,0.000003417244,0.0005606778],"genre_scores_gemma":[0.9974732,0.001144521,0.0008126207,0.0003059717,0.00007856711,0.00001193632,0.00001956204,0.00002026244,0.0001333193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02466267,"threshold_uncertainty_score":0.4451135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316834685014746,"score_gpt":0.2340900447079196,"score_spread":0.2209216978577721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}