{"id":"W2169123048","doi":"10.1101/gr.190470.115","title":"Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells","year":2015,"lang":"en","type":"article","venue":"Genome Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Biotechnology and Biological Sciences Research Council; National Institute for Health and Care Research; University College London Hospitals NHS Foundation Trust; European Commission; Royal Marsden NHS Foundation Trust; FP7 People: Marie-Curie Actions; Cancer Research UK; Wellcome Trust; Wellcome; European Molecular Biology Organization","keywords":"Biology; Mitochondrial DNA; Genome; Somatic cell; Nuclear DNA; Genetics; Nuclear gene; mitochondrial fusion; DNA repair; Heavy strand; Molecular biology; Mitochondrion; DNA; Cell biology; Gene; Transfer RNA; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000685569,0.0001152671,0.0002133286,0.0001052087,0.0001149727,0.00001357998,0.0004529271,0.0001689805,0.0004045598],"category_scores_gemma":[0.00007098489,0.00008647174,0.0001126647,0.0001952808,0.0003746375,0.000003249765,0.0001420335,0.0002030467,0.00004740704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003789232,"about_ca_system_score_gemma":0.0002271191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004304496,"about_ca_topic_score_gemma":0.0001913364,"domain_scores_codex":[0.9982517,0.0004048243,0.0003284251,0.0002883145,0.0004076249,0.0003191329],"domain_scores_gemma":[0.9988666,0.00002859065,0.0000464197,0.0005445559,0.0003768034,0.0001370125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001680447,0.00006582976,0.00003847429,0.00005454876,0.00005303443,0.000001970767,0.001994411,0.00006003474,0.9961728,0.0002849238,0.0009501646,0.0001557878],"study_design_scores_gemma":[0.001241697,0.001350778,0.0003073799,0.00001576589,0.0000247,0.00000534229,0.001062834,0.00001048905,0.8990411,0.0005466255,0.09622484,0.0001685144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948364,0.001336172,0.0003189079,0.0002949392,0.0004171189,0.0004655047,0.00003724219,0.00000549941,0.002288148],"genre_scores_gemma":[0.996866,0.0003201777,0.0004135004,0.00006585201,0.0007279893,0.00005344365,0.00004866481,0.00003342642,0.001470956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09713174,"threshold_uncertainty_score":0.4429646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0697652714493925,"score_gpt":0.3469250939319095,"score_spread":0.277159822482517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}