{"id":"W2169245878","doi":"10.1016/j.jmb.2015.08.019","title":"Structural Insights into KCTD Protein Assembly and Cullin3 Recognition","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network; Canada Research Chairs; University of Toronto","funders":"Basic Energy Sciences; Scheme for Promotion of Academic and Research Collaboration; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canada Research Chairs; Ontario Ministry of Health and Long-Term Care; Hospital for Sick Children; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ubiquitin ligase; Ubiquitin; Plasma protein binding; Protein structure; Biology; Crystallography; Cell biology; Chemistry; Biophysics; Stereochemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001924368,0.0004116051,0.000251487,0.0001584604,0.0004744579,0.0006403609,0.0004577806,0.0004599033,0.001967043],"category_scores_gemma":[0.0001963513,0.0002743715,0.00031751,0.0001704014,0.0003404964,0.0006575694,0.0002437784,0.001190051,0.0005672838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001263671,"about_ca_system_score_gemma":0.0005681306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002108405,"about_ca_topic_score_gemma":0.002319705,"domain_scores_codex":[0.9999458,0.000005261411,0.000006234991,0.00001204482,0.00001340253,0.00001732661],"domain_scores_gemma":[0.9999193,0.00001890374,0.00001671617,0.00001013552,0.00001321589,0.00002175608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006126619,0.00009240986,0.001191092,0.0001878424,0.00001849807,0.0007859856,0.0001404048,0.00293224,0.9752009,0.01197055,0.0007313353,0.00613614],"study_design_scores_gemma":[0.00004132716,0.00009994466,0.002828353,0.00001901719,0.00003090224,0.0007424612,0.0001826228,0.01942046,0.963418,0.002550658,0.01064357,0.00002265708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974083,0.003288381,0.01447683,0.001570315,0.0001901426,0.000028072,0.0005288646,0.0002870195,0.005547395],"genre_scores_gemma":[0.9896926,0.001573083,0.005658305,0.0001594326,0.00002171604,0.000007393642,0.0005381803,0.00002339423,0.00232581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002108405,"threshold_uncertainty_score":0.009168565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238002365604136,"score_gpt":0.2782562493452826,"score_spread":0.254456012784869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}