{"id":"W2169259508","doi":"10.1182/blood-2005-04-1356","title":"Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet  -granule biogenesis","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"","keywords":"Platelet; Granule (geology); Cell biology; Hermansky–Pudlak syndrome; Biogenesis; Biology; Thrombopoiesis; Dense granule; Endosome; Secretion; Megakaryocyte; Chemistry; Platelet activation; Intracellular; Biochemistry; Internal medicine; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030643,0.0003743855,0.0002226113,0.0002128664,0.0002235073,0.0002877852,0.000115873,0.0003807229,0.0008079577],"category_scores_gemma":[0.0001822065,0.0001746754,0.0001468726,0.0001487179,0.0002335998,0.0002662801,0.0002382026,0.0002405853,0.0004405162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143416,"about_ca_system_score_gemma":0.0001483945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006601608,"about_ca_topic_score_gemma":0.0003761363,"domain_scores_codex":[0.9999108,0.00001915803,0.0000129646,0.0000216137,0.00002148716,0.00001398283],"domain_scores_gemma":[0.9998749,0.00001947956,0.00004410638,0.0000129099,0.00001330477,0.00003523682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699241,0.000007251579,0.001895497,0.0000495401,0.000006023799,0.0004991425,0.00002640896,0.00006885391,0.9953875,0.0001381645,0.00004168803,0.001710024],"study_design_scores_gemma":[0.00005783476,0.0004479687,0.1219789,0.00003188239,0.00005781315,0.01456611,0.0002083902,0.003658708,0.8513924,0.0004876991,0.007092876,0.00001925519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954146,0.002798003,0.001165616,0.00007448807,0.000004933139,0.000004775502,0.0001525443,0.00003891205,0.0003460989],"genre_scores_gemma":[0.996752,0.0008911645,0.00144577,0.00001962927,0.000003058869,0.000008875373,0.0005415942,0.0000128809,0.0003249365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008079577,"threshold_uncertainty_score":0.002702951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02303703077842534,"score_gpt":0.2488249416995025,"score_spread":0.2257879109210772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}