{"id":"W2169259508","doi":"10.1182/blood-2005-04-1356","title":"Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet  -granule biogenesis","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"","keywords":"Platelet; Granule (geology); Cell biology; Hermansky–Pudlak syndrome; Biogenesis; Biology; Thrombopoiesis; Dense granule; Endosome; Secretion; Megakaryocyte; Chemistry; Platelet activation; Intracellular; Biochemistry; Internal medicine; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573377,0.00009925853,0.0002796466,0.00006445761,0.00002116121,0.000001511424,0.00005688268,0.00008224138,0.00007899375],"category_scores_gemma":[0.00002731844,0.00006618472,0.0000825617,0.0001901645,0.0001001071,0.00002850296,0.00005209415,0.00008431346,0.000004555346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000127908,"about_ca_system_score_gemma":0.00005415108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001387805,"about_ca_topic_score_gemma":0.00009708172,"domain_scores_codex":[0.9992037,0.00005343639,0.0002963082,0.000160022,0.0001529845,0.0001335378],"domain_scores_gemma":[0.9995236,0.0000230198,0.0001049059,0.0002606667,0.00004840731,0.00003942764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002509275,0.0006235391,0.0139611,0.0002086861,0.00008562394,0.000005608055,0.0003652272,0.000006909843,0.9822952,0.0001035516,0.0002607029,0.001832974],"study_design_scores_gemma":[0.005881062,0.0003973407,0.09140498,0.0002343893,0.0001106833,0.00003806753,0.0001487736,0.00006767684,0.8954656,0.00005613874,0.006099829,0.000095512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966386,0.001001314,0.000004582244,0.0004284055,0.00004440068,0.000454907,0.00001243392,0.00001112314,0.001404229],"genre_scores_gemma":[0.9983042,0.0001301335,0.0008077087,0.0003184234,0.00006816051,0.00002693548,0.000005099082,0.00001064567,0.0003286931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0868296,"threshold_uncertainty_score":0.2698934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02303703077842534,"score_gpt":0.2488249416995025,"score_spread":0.2257879109210772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}