{"id":"W2169278779","doi":"10.1093/annonc/mdv188","title":"Titration of signalling output: insights into clinical combinations of MEK and AKT inhibitors","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Institute of Cancer Research; Cancer Research UK; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; MEK inhibitor; Medicine; Growth inhibition; Cell growth; Cancer research; Pharmacology; Cell biology; Biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009300312,0.0006032044,0.0007350581,0.0005401967,0.0002632147,0.001380895,0.0005455264,0.0004120303,0.003787047],"category_scores_gemma":[0.000967379,0.0002617058,0.0004455324,0.0004321556,0.0003903003,0.0009671638,0.000362218,0.001981967,0.0006724566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860399,"about_ca_system_score_gemma":0.0006129725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002785871,"about_ca_topic_score_gemma":0.001162231,"domain_scores_codex":[0.9996963,0.00008165275,0.00002551201,0.00004916649,0.00007628153,0.00007122627],"domain_scores_gemma":[0.9998061,0.00007271682,0.00002967624,0.00002543071,0.00002365507,0.0000424589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01971348,0.003731196,0.005427667,0.0007696872,0.0003105612,0.0004777042,0.0002651481,0.00877561,0.5900703,0.004960707,0.0039762,0.3615218],"study_design_scores_gemma":[0.008339379,0.07000819,0.03500238,0.0003508395,0.001314132,0.003404868,0.0007780211,0.03195085,0.7554067,0.01039807,0.08278811,0.0002584941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465008,0.0240041,0.009234559,0.002484663,0.000417675,0.0003675178,0.0005318053,0.000384692,0.01607413],"genre_scores_gemma":[0.989872,0.005016209,0.002756644,0.0002336111,0.00006816792,0.0001032529,0.0001854223,0.00004551376,0.001719179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003787047,"threshold_uncertainty_score":0.01266891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308884651518638,"score_gpt":0.3920301638741505,"score_spread":0.2611416987222868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}