{"id":"W2169338224","doi":"10.1172/jci32849","title":"Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Vagus Nerve Stimulation Research","field":"Neuroscience","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation; McMaster University; Institut de France","keywords":"Vagus nerve; Tricyclic; Inflammation; Inflammatory bowel disease; Medicine; Colitis; Tonic (physiology); Monoamine neurotransmitter; Irritable bowel syndrome; Proinflammatory cytokine; Tricyclic antidepressant; Imipramine; Antidepressant; Internal medicine; Immunology; Pharmacology; Endocrinology; Disease; Serotonin; Pathology; Receptor; Stimulation; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254871,0.0008471831,0.000471574,0.001119618,0.0002646685,0.0004195217,0.0002318152,0.0007392692,0.00197286],"category_scores_gemma":[0.0002352917,0.0004993737,0.0003334924,0.0003490011,0.000352648,0.0003125848,0.000271739,0.001634389,0.000482579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004528396,"about_ca_system_score_gemma":0.0001847967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006647769,"about_ca_topic_score_gemma":0.001426573,"domain_scores_codex":[0.9996938,0.00008930107,0.00003190955,0.0000558412,0.00006835585,0.00006084753],"domain_scores_gemma":[0.9997161,0.00002575595,0.0001014067,0.00002491144,0.00001707337,0.0001147722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001420935,0.000576001,0.001781864,0.00007698632,0.00003732563,0.0003067842,0.00005936907,0.0001168497,0.9920931,0.0001608679,0.0002198856,0.003149894],"study_design_scores_gemma":[0.00140186,0.01572792,0.1386472,0.0002172874,0.0003795702,0.004894176,0.0003886233,0.00815369,0.8224282,0.0008477125,0.006845385,0.00006833778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949763,0.001600099,0.001081544,0.0002995995,0.00004639741,0.00005769484,0.0004926358,0.0001776181,0.001268221],"genre_scores_gemma":[0.991747,0.002187166,0.002371293,0.0001976323,0.00002162724,0.0001589546,0.0006591273,0.00003258411,0.002624545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197286,"threshold_uncertainty_score":0.006599844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1671487793872885,"score_gpt":0.3957307857966534,"score_spread":0.2285820064093649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}