{"id":"W2169427529","doi":"10.1080/13506120601116419","title":"Heparan sulfate as a therapeutic target in amyloidogenesis: prospects and possible complications","year":2007,"lang":"en","type":"review","venue":"Amyloid","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Heparan sulfate; Fibrillogenesis; In vivo; Perlecan; Chemistry; Amyloid (mycology); Extracellular matrix; Biochemistry; In vitro; Cell biology; Glycosaminoglycan; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004287669,0.0004656256,0.0008146839,0.0003020654,0.0001290344,0.00007913599,0.0004863589,0.0004887492,0.00003117539],"category_scores_gemma":[0.000042452,0.0004037819,0.000221102,0.0004856825,0.0001949919,0.000005776872,0.0002246812,0.0003681039,0.00007512818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006595807,"about_ca_system_score_gemma":0.0004743294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002102904,"about_ca_topic_score_gemma":0.0001858946,"domain_scores_codex":[0.9975904,0.000156474,0.0005231691,0.0008437237,0.0002371351,0.0006490952],"domain_scores_gemma":[0.9987915,0.00003756274,0.000157145,0.0007345945,0.00008046289,0.0001987617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000703429,0.0002133732,0.0003343897,0.003190792,0.0002356224,0.00004715362,0.00004265021,0.00000180941,0.002667935,0.0006141823,0.0002095283,0.9923722],"study_design_scores_gemma":[0.0003901596,0.000242277,0.0003028087,0.0008120114,0.00006746005,0.0001595213,0.00001393794,0.000006099559,0.001063796,0.0002329874,0.9962263,0.000482697],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001598887,0.9927324,0.0001266861,0.00005584781,0.00005371156,0.0015492,0.00008967526,0.00002003099,0.003773573],"genre_scores_gemma":[0.002893244,0.9934597,0.0003769902,0.0001438778,0.0001548196,0.0005376255,0.0004660331,0.00008646336,0.001881254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9960167,"threshold_uncertainty_score":0.9998414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05107228453232737,"score_gpt":0.3696414525639463,"score_spread":0.3185691680316189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}