{"id":"W2169519275","doi":"10.1158/0008-5472.can-13-1055","title":"Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Neuregulin; Breast cancer; Autocrine signalling; Neuregulin 1; Medicine; Cancer research; Trastuzumab; Lapatinib; Cancer; In vivo; Oncology; Internal medicine; Receptor; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009163353,0.0001840494,0.0001351603,0.0001529335,0.00009149819,0.0002259403,0.00009864977,0.00009609132,0.001353125],"category_scores_gemma":[0.00006551291,0.00005789947,0.0001277803,0.00008650922,0.0001355901,0.0001189442,0.0001666499,0.0002903811,0.0003027349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982908,"about_ca_system_score_gemma":0.0001660298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003671107,"about_ca_topic_score_gemma":0.0009596532,"domain_scores_codex":[0.9999312,0.00001252869,0.00000277933,0.00001137349,0.00002227325,0.00001980673],"domain_scores_gemma":[0.9999583,0.000007701904,0.00001050124,0.000004851669,0.000004289593,0.00001440505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008801422,0.00002330024,0.0008672914,0.0000301671,0.000005045473,0.00006954733,0.000009247534,0.00006605641,0.9953194,0.0001230914,0.000079502,0.003319125],"study_design_scores_gemma":[0.00001561427,0.0002089555,0.0241748,0.000005787217,0.00001935411,0.0005383508,0.00006049416,0.001496092,0.9668628,0.0001263692,0.006488217,0.000003114181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913546,0.002846022,0.002075524,0.0001407567,0.00002103421,0.00001999857,0.0002106508,0.00007803539,0.003253303],"genre_scores_gemma":[0.995608,0.001280577,0.001164087,0.00003861313,0.000007565085,0.00001216925,0.0001750367,0.000007661973,0.001706241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001353125,"threshold_uncertainty_score":0.004526615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06370755747525297,"score_gpt":0.3978460224394583,"score_spread":0.3341384649642053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}