{"id":"W2169565764","doi":"10.1002/rmv.674","title":"Multiple levels of PKR inhibition during HIV‐1 replication","year":2010,"lang":"en","type":"review","venue":"Reviews in Medical Virology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Protein kinase R; EIF-2 kinase; Biology; Activator (genetics); Interferon; RNA; Viral replication; Protein kinase A; Virology; Kinase; Virus; Cell biology; Mitogen-activated protein kinase kinase; Gene; Biochemistry; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003538251,0.0004172181,0.0006685281,0.0002489048,0.0002651757,0.0009583183,0.0003272213,0.0005042448,0.003187875],"category_scores_gemma":[0.0003300158,0.0002231422,0.0004016117,0.0001759649,0.0002422483,0.0007160283,0.0003907454,0.001652814,0.001058103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005442568,"about_ca_system_score_gemma":0.0003927825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851364,"about_ca_topic_score_gemma":0.0002362894,"domain_scores_codex":[0.9994853,0.00008248555,0.00004999697,0.0001255224,0.0001437211,0.0001129402],"domain_scores_gemma":[0.9997901,0.00003631402,0.00005673859,0.00003690847,0.00003901242,0.00004092594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004600821,0.00009938896,0.0003702293,0.000236232,0.00001768401,0.00007403464,0.00002683375,0.0001775641,0.9859955,0.0004626841,0.0002364784,0.0118434],"study_design_scores_gemma":[0.00003459166,0.0009028567,0.004246297,0.00003753761,0.00004608472,0.0004543504,0.00003335039,0.0008350291,0.9842713,0.0003562952,0.008768999,0.00001322472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8585331,0.09619167,0.02150551,0.001381773,0.0006508611,0.0002782783,0.001080862,0.001086145,0.01929188],"genre_scores_gemma":[0.9785666,0.008835823,0.004983491,0.0002012397,0.0001178395,0.0001236136,0.0005453877,0.00003874417,0.006587266],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003187875,"threshold_uncertainty_score":0.01066446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04048164097706108,"score_gpt":0.3578056120852873,"score_spread":0.3173239711082262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}