{"id":"W2169589212","doi":"10.1128/jb.187.12.4064-4076.2005","title":"A VicRK Signal Transduction System in <i>Streptococcus mutans</i> Affects <i>gtfBCD</i> , <i>gbpB</i> , and <i>ftf</i> Expression, Biofilm Formation, and Genetic Competence Development","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mutant; Operon; Streptococcus mutans; Response regulator; Biofilm; Histidine kinase; Signal transduction; Wild type; Two-component regulatory system; Gene; Microbiology; Genetics; Biochemistry; Molecular biology; Cell biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801661,0.0004374335,0.0002984426,0.0001752346,0.0001247525,0.000294605,0.0002735484,0.0002772096,0.0005732133],"category_scores_gemma":[0.0001450021,0.0001603105,0.0003291841,0.0001724007,0.000231015,0.0001867594,0.0003420369,0.0005288593,0.000264157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000472002,"about_ca_system_score_gemma":0.0002581504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008519706,"about_ca_topic_score_gemma":0.0008080821,"domain_scores_codex":[0.9997479,0.00004945817,0.0000347839,0.00004707473,0.00007367152,0.00004710877],"domain_scores_gemma":[0.9998801,0.00001940734,0.00004724936,0.00001861494,0.00001047296,0.00002424879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002119868,0.00001189396,0.00006611729,0.00001029946,0.000001553169,0.00001787715,0.000006587601,0.00002314205,0.9995037,0.00003827834,0.000005504278,0.0002938307],"study_design_scores_gemma":[0.000003922908,0.00009520738,0.001040027,0.00000237406,0.000007503274,0.0002004071,0.00001758823,0.0005204556,0.9975672,0.00001393686,0.0005274948,0.00000395198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948344,0.0002112348,0.004063946,0.00006383683,0.00001557179,0.00002668172,0.000175414,0.00007035599,0.0005385089],"genre_scores_gemma":[0.9927394,0.0001691959,0.005070773,0.00002734789,0.000004822992,0.00003328959,0.00063144,0.00003416872,0.001289579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008519706,"threshold_uncertainty_score":0.003424704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009860125126853773,"score_gpt":0.2364640657602873,"score_spread":0.2266039406334336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}