{"id":"W2169589212","doi":"10.1128/jb.187.12.4064-4076.2005","title":"A VicRK Signal Transduction System in <i>Streptococcus mutans</i> Affects <i>gtfBCD</i> , <i>gbpB</i> , and <i>ftf</i> Expression, Biofilm Formation, and Genetic Competence Development","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mutant; Operon; Streptococcus mutans; Response regulator; Biofilm; Histidine kinase; Signal transduction; Wild type; Two-component regulatory system; Gene; Microbiology; Genetics; Biochemistry; Molecular biology; Cell biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813363,0.0002084238,0.0005103052,0.0002514207,0.0001044963,0.00002583742,0.00005263331,0.0001422684,0.00003852248],"category_scores_gemma":[0.00001524652,0.000159362,0.00005908009,0.0001873129,0.0001036806,0.0002590592,0.00002573285,0.0002399878,0.000005304947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708429,"about_ca_system_score_gemma":0.0001219495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007143937,"about_ca_topic_score_gemma":0.00002346386,"domain_scores_codex":[0.9985937,0.0001094443,0.0007046202,0.0002086233,0.0001366885,0.0002469512],"domain_scores_gemma":[0.9991213,0.00007944641,0.00034347,0.000112437,0.0001465864,0.0001967725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004808675,0.0003826252,0.2569616,0.0003253292,0.0001242873,0.0002726784,0.001018311,0.00006364252,0.6977986,0.00002071528,0.0002218661,0.04232948],"study_design_scores_gemma":[0.01093987,0.002349925,0.7144389,0.001824327,0.000251068,0.02362484,0.0006630196,0.0004802276,0.2196641,0.00002544803,0.02529403,0.0004443105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965551,0.000796972,0.001573576,0.0003183395,0.000154237,0.0004427055,0.000004624637,0.00002179857,0.0001326469],"genre_scores_gemma":[0.9932961,0.0002311494,0.006029942,0.0002036968,0.0001668948,0.00003659927,0.000007587851,0.00001432526,0.00001372963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4781345,"threshold_uncertainty_score":0.6498592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009860125126853773,"score_gpt":0.2364640657602873,"score_spread":0.2266039406334336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}