{"id":"W2169657531","doi":"10.1210/me.2005-0052","title":"PITX Genes Are Required for Cell Survival and Lhx3 Activation","year":2005,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Indiana University-Purdue University Indianapolis; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Food and Drug Administration","keywords":"Biology; Transcription factor; Thyrotropic cell; PITX2; Cell biology; Gonadotropic cell; Doublesex; SOX9; Pituitary gland; Internal medicine; Genetics; Endocrinology; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006630654,0.0003614823,0.0001964303,0.000164789,0.0002681298,0.0003475147,0.0002288752,0.0002193728,0.003309249],"category_scores_gemma":[0.0001569194,0.0002103096,0.0002006943,0.0001133279,0.0002169772,0.0002287133,0.000446279,0.0004320981,0.001135173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333318,"about_ca_system_score_gemma":0.0003313949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000737229,"about_ca_topic_score_gemma":0.001126044,"domain_scores_codex":[0.9998976,0.000008087856,0.000006654495,0.00001609973,0.00004393094,0.0000275527],"domain_scores_gemma":[0.9998775,0.00001477821,0.00003619892,0.00001110215,0.00001453062,0.00004589705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308196,0.000009843918,0.0006650024,0.00003884659,0.000005377965,0.0004606519,0.00002312634,0.00005016519,0.9941912,0.0003153569,0.0002574295,0.003852156],"study_design_scores_gemma":[0.00004536366,0.0001256299,0.04088151,0.000009958404,0.0000239348,0.002883495,0.00007370864,0.00111401,0.9330345,0.0002997979,0.02149675,0.00001139032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815916,0.002799665,0.006693154,0.0002972713,0.0001180835,0.00002893316,0.002063878,0.0005694649,0.005838003],"genre_scores_gemma":[0.9805043,0.001003905,0.002018369,0.00008516038,0.00002760859,0.00004611889,0.002554182,0.0001111843,0.0136492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003309249,"threshold_uncertainty_score":0.01107055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03280371758292949,"score_gpt":0.2674141617626978,"score_spread":0.2346104441797683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}