{"id":"W2169657531","doi":"10.1210/me.2005-0052","title":"PITX Genes Are Required for Cell Survival and Lhx3 Activation","year":2005,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Indiana University-Purdue University Indianapolis; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Food and Drug Administration","keywords":"Biology; Transcription factor; Thyrotropic cell; PITX2; Cell biology; Gonadotropic cell; Doublesex; SOX9; Pituitary gland; Internal medicine; Genetics; Endocrinology; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003915808,0.0001081729,0.0001406087,0.00006677222,0.0001155776,0.00002805203,0.0001143463,0.00005125726,0.00004419205],"category_scores_gemma":[0.0001043596,0.0001082092,0.00004660251,0.00006616032,0.00006599543,0.00007836179,0.00006205119,0.00007575758,0.00002555994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001908106,"about_ca_system_score_gemma":0.000009918447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000062535,"about_ca_topic_score_gemma":0.000002826772,"domain_scores_codex":[0.9990547,0.00007893788,0.0001300997,0.0003348264,0.00008913358,0.0003123388],"domain_scores_gemma":[0.9996234,0.00008932367,0.00007075202,0.000146,0.00002333137,0.00004726337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002920514,0.00003719128,0.0001245997,0.00001064752,0.000002472675,0.00001149105,0.00003656654,0.00005069849,0.9833879,0.005303963,0.0001000185,0.01090523],"study_design_scores_gemma":[0.0005433032,0.00007616373,0.0001520702,0.000003561781,0.000006318578,0.00001626762,0.00003839955,0.000493088,0.9410695,0.0004183119,0.05706859,0.0001143953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896441,0.0001712692,0.007121459,0.001277403,0.0001777862,0.0002144145,0.000004932848,0.00006757697,0.001321056],"genre_scores_gemma":[0.997706,0.00006371608,0.001128048,0.0006409428,0.00009509124,0.00002071526,0.000002322619,0.00002557748,0.0003176038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05696857,"threshold_uncertainty_score":0.4412642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03280371758292949,"score_gpt":0.2674141617626978,"score_spread":0.2346104441797683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}