{"id":"W2169763871","doi":"10.1128/mcb.20.22.8513-8525.2000","title":"The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Protein tyrosine phosphatase; Receptor tyrosine kinase; Cell biology; Tropomyosin receptor kinase C; Tyrosine kinase; ROR1; Morphogenesis; Phosphatase; Proto-oncogene tyrosine-protein kinase Src; Kinase; Tyrosine; Platelet-derived growth factor receptor; Signal transduction; Receptor; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004615217,0.000413183,0.0003803787,0.00003857085,0.0003931907,0.00006240761,0.000376672,0.0003375317,0.0001278112],"category_scores_gemma":[0.0001839669,0.0002854498,0.0001824347,0.0001875874,0.0006757194,0.00001406292,0.0001652378,0.0001145498,0.000003668792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001757714,"about_ca_system_score_gemma":0.00008274194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004019442,"about_ca_topic_score_gemma":0.00001173638,"domain_scores_codex":[0.9977982,0.0002842368,0.0005189732,0.0007560449,0.0001522926,0.0004902775],"domain_scores_gemma":[0.9984903,0.0001514082,0.00024268,0.0007931339,0.0001844863,0.0001379642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001446581,0.00008986879,0.000168182,0.00002483803,0.0002087447,0.000006586129,0.00004032872,0.00001639396,0.9549311,0.001806856,0.000938168,0.04032238],"study_design_scores_gemma":[0.001898558,0.0007150134,0.0001098831,0.00002763308,0.0001576288,0.000005630547,0.00007692001,0.0001661623,0.9495384,0.0008945063,0.04608213,0.0003275673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.891019,0.09756276,0.006898548,0.00110599,0.00007649256,0.001044629,0.002262249,0.00001981757,0.00001054468],"genre_scores_gemma":[0.9919437,0.001739455,0.001299652,0.000439937,0.0001621757,0.0001609389,0.003941816,0.00005766642,0.0002546585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1009247,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00690776689317422,"score_gpt":0.2206788915965416,"score_spread":0.2137711247033674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}