{"id":"W2169763871","doi":"10.1128/mcb.20.22.8513-8525.2000","title":"The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":287,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Biology; Protein tyrosine phosphatase; Receptor tyrosine kinase; Cell biology; Tropomyosin receptor kinase C; Tyrosine kinase; ROR1; Morphogenesis; Phosphatase; Proto-oncogene tyrosine-protein kinase Src; Kinase; Tyrosine; Platelet-derived growth factor receptor; Signal transduction; Receptor; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732305,0.0006544552,0.0002904902,0.0002861564,0.0003283585,0.0005502827,0.0003858285,0.000379651,0.001617859],"category_scores_gemma":[0.0002048754,0.0003543683,0.0003204779,0.0001901722,0.0003160139,0.0003451275,0.0004752809,0.0006598394,0.000787637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000637904,"about_ca_system_score_gemma":0.0004823655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006183,"about_ca_topic_score_gemma":0.001905613,"domain_scores_codex":[0.9997112,0.00003470211,0.00003129584,0.00004800198,0.0001104051,0.00006439869],"domain_scores_gemma":[0.9997602,0.00002283532,0.00008451999,0.00002117587,0.00001959193,0.00009176098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112152,0.00002316982,0.0002869906,0.00003256571,0.00000711273,0.0001583056,0.000008524627,0.00009536315,0.9982925,0.0002015783,0.00006005463,0.0007216473],"study_design_scores_gemma":[0.00005878427,0.00016061,0.0234806,0.0000157493,0.00002999376,0.001219288,0.00006346168,0.004077654,0.963263,0.0001834266,0.007434179,0.0000132662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908419,0.002783844,0.003591487,0.0002528128,0.00005446842,0.00003514023,0.000588098,0.00013508,0.00171723],"genre_scores_gemma":[0.9935219,0.0008131263,0.001418494,0.00006196647,0.00001539236,0.00004010559,0.0010115,0.00002578837,0.003091855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617859,"threshold_uncertainty_score":0.005412221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00690776689317422,"score_gpt":0.2206788915965416,"score_spread":0.2137711247033674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}