{"id":"W2169763883","doi":"10.1186/s13041-015-0107-0","title":"Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes","year":2015,"lang":"en","type":"review","venue":"Molecular Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; University of Calgary; Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Glutamate receptor; Ionotropic effect; Metabotropic glutamate receptor 5; Neuroscience; Metabotropic glutamate receptor; Metabotropic glutamate receptor 8; Metabotropic glutamate receptor 1; Biology; Neurodegeneration; Cell biology; Glutamatergic; Metabotropic glutamate receptor 6; Metabotropic glutamate receptor 7; Receptor; Signal transduction; Chemistry; Biochemistry; Medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860689,0.0009642632,0.001037722,0.00068806,0.0002436028,0.0009409586,0.0005792734,0.0007884075,0.00129648],"category_scores_gemma":[0.0001795923,0.0001692172,0.0005725097,0.0005447483,0.00027377,0.0009367306,0.000476438,0.0005833341,0.001193694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000620187,"about_ca_system_score_gemma":0.0005016639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007292068,"about_ca_topic_score_gemma":0.0007988305,"domain_scores_codex":[0.9998374,0.00002675755,0.00003030562,0.00003150394,0.00003615108,0.00003794577],"domain_scores_gemma":[0.9999431,0.00001059804,0.00001838116,0.000002424282,0.00001748592,0.000007951697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009197969,0.00009518689,0.001880718,0.03006352,0.0006098911,0.003525844,0.0007625446,0.001987582,0.3368329,0.01673206,0.01689191,0.5896981],"study_design_scores_gemma":[0.00009697054,0.0007422835,0.009761009,0.002361121,0.0009155647,0.005467853,0.0006350944,0.001007653,0.08426042,0.005522802,0.8890986,0.0001305484],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00868891,0.9852011,0.001952077,0.0003817027,0.0002727269,0.00002561923,0.000168808,0.00009437323,0.003214647],"genre_scores_gemma":[0.04592775,0.9494898,0.001138492,0.0002765006,0.0002151008,0.00003226624,0.0003005676,0.00001006363,0.002609352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00129648,"threshold_uncertainty_score":0.004499793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04737271488943582,"score_gpt":0.3386620584580872,"score_spread":0.2912893435686514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}