{"id":"W2169784480","doi":"10.1016/s0960-894x(03)00161-6","title":"Identification of a broad-Spectrum azasordarin with improved pharmacokinetic properties","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Pharmacokinetics; Broad spectrum; Antifungal; Stereochemistry; Derivative (finance); Combinatorial chemistry; Identification (biology); Pharmacology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002167796,0.0003720067,0.0003996961,0.00003082282,0.00009364897,0.00003387062,0.0003834944,0.0001481941,0.002299845],"category_scores_gemma":[0.0001780866,0.0003118467,0.0001113168,0.0002840932,0.0003880297,0.00008184092,0.00003468945,0.0003405906,0.00001098759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506548,"about_ca_system_score_gemma":0.0001459891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003044289,"about_ca_topic_score_gemma":0.000001357025,"domain_scores_codex":[0.9979218,0.00002178089,0.0006114566,0.0005538705,0.0004518781,0.0004392289],"domain_scores_gemma":[0.9986945,0.00005175058,0.0003662696,0.0006287461,0.0000762967,0.0001824327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353696,0.0001144634,0.0003688364,0.0009185448,0.0001344328,0.00002617689,0.0001972765,0.000004521411,0.9977116,0.000003667506,0.0001796175,0.0002054817],"study_design_scores_gemma":[0.001024259,0.00001087198,0.00004624199,0.000180834,0.0001962136,0.0001724525,0.0004855254,0.00008497646,0.9963988,0.000007832508,0.001026996,0.0003650012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99479,0.0004671701,0.0001361008,0.001097496,0.00005958032,0.00009456502,0.00001781381,0.0001054389,0.003231789],"genre_scores_gemma":[0.9984728,0.00004189618,0.00004481503,0.0001392293,0.000213072,0.00003965488,0.00002322682,0.00005464662,0.0009706668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003682745,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889453861317837,"score_gpt":0.1941992888264051,"score_spread":0.1853047502132267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}