{"id":"W2169784480","doi":"10.1016/s0960-894x(03)00161-6","title":"Identification of a broad-Spectrum azasordarin with improved pharmacokinetic properties","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Pharmacokinetics; Broad spectrum; Antifungal; Stereochemistry; Derivative (finance); Combinatorial chemistry; Identification (biology); Pharmacology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003066784,0.0004135871,0.0006515491,0.0002917303,0.0002126993,0.0004757683,0.0003998061,0.0004300106,0.001329042],"category_scores_gemma":[0.0003454573,0.0001432693,0.0003246011,0.0001984431,0.000259969,0.0003366285,0.0002660549,0.0006404293,0.000456964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884684,"about_ca_system_score_gemma":0.0004040886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004461127,"about_ca_topic_score_gemma":0.000760559,"domain_scores_codex":[0.99986,0.00003111508,0.00001264891,0.00002683275,0.00002704147,0.00004227814],"domain_scores_gemma":[0.9999057,0.00001989573,0.00001212424,0.00001587118,0.00001961071,0.00002665401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009263357,0.0002282881,0.0009248435,0.00004803588,0.00003250815,0.0005107941,0.00003742436,0.0003359166,0.9804985,0.0003026713,0.0002382296,0.01591643],"study_design_scores_gemma":[0.0005034891,0.005418118,0.008475504,0.00001055096,0.0001933235,0.004413105,0.00005123589,0.002261375,0.9701302,0.0002547284,0.008263318,0.00002501533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893316,0.002890132,0.003897659,0.0004044138,0.00005419755,0.0001550616,0.0003801058,0.0001108734,0.002775862],"genre_scores_gemma":[0.9917247,0.00110872,0.004323919,0.0002193369,0.00003587673,0.00004166547,0.0009017805,0.00002178621,0.001622358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329042,"threshold_uncertainty_score":0.004446089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889453861317837,"score_gpt":0.1941992888264051,"score_spread":0.1853047502132267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}