{"id":"W2169784899","doi":"10.1161/circresaha.107.155531","title":"Transient Receptor Potential Channel 6–Mediated, Localized Cytosolic [Na <sup>+</sup> ] Transients Drive Na <sup>+</sup> /Ca <sup>2+</sup> Exchanger–Mediated Ca <sup>2+</sup> Entry in Purinergically Stimulated Aorta Smooth Muscle Cells","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Simon Fraser University; University of Calgary","funders":"","keywords":"Cytosol; Sodium-calcium exchanger; Biophysics; Chemistry; Membrane potential; Ion transporter; Intracellular; Vascular smooth muscle; Internal medicine; Endocrinology; Biochemistry; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.005240168,0.001951138,0.002095879,0.003991281,0.001764891,0.000720539,0.002508372,0.002185616,0.006082214],"category_scores_gemma":[0.001896742,0.001928695,0.001075348,0.007928859,0.001647679,0.001434054,0.0005704982,0.004013707,0.002715728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001522116,"about_ca_system_score_gemma":0.001024216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710138,"about_ca_topic_score_gemma":0.00007991434,"domain_scores_codex":[0.9764064,0.003488264,0.003514081,0.004315318,0.006635991,0.005639971],"domain_scores_gemma":[0.9911097,0.00226271,0.0006007078,0.001781103,0.001625933,0.002619906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001794888,0.00246751,0.000346392,0.000413235,0.0001427731,0.0007704711,0.02345769,0.8962543,0.06575668,0.00003441438,0.004609403,0.00395227],"study_design_scores_gemma":[0.01223372,0.0007684271,0.001352393,0.0005344636,0.0001072934,0.00005008735,0.004957563,0.9532846,0.01415098,0.00009444085,0.01044005,0.002026049],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831065,0.0003818623,0.005400936,0.001900164,0.0008946378,0.005617599,0.001064519,0.0006945953,0.0009392049],"genre_scores_gemma":[0.992112,0.001088476,0.000149762,0.0009574929,0.0013914,0.0004605873,0.001940955,0.0004991078,0.001400263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05703025,"threshold_uncertainty_score":0.9995347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03932319292964295,"score_gpt":0.3018586961501351,"score_spread":0.2625355032204921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}