{"id":"W2169862738","doi":"10.1093/jnci/djj465","title":"Population BRCA1 and BRCA2 Mutation Frequencies and Cancer Penetrances: A Kin–Cohort Study in Ontario, Canada","year":2006,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":685,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Ovarian cancer; Medicine; Population; Cancer; Oncology; Internal medicine; Breast cancer; Incidence (geometry); Cancer registry; Germline mutation; Relative risk; Confidence interval; Genetics; Mutation; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615232,0.0003133086,0.0003941476,0.000656831,0.002149663,0.0007288915,0.0006992186,0.0003319821,0.001467872],"category_scores_gemma":[0.001273374,0.0004413838,0.0004275483,0.002103979,0.0006360036,0.0003103488,0.0005895922,0.0004187216,0.0001718794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01290355,"about_ca_system_score_gemma":0.01152038,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9851297,"about_ca_topic_score_gemma":0.9911364,"domain_scores_codex":[0.9994162,0.00004792594,0.00003272966,0.0001288782,0.0001914402,0.0001828118],"domain_scores_gemma":[0.9989917,0.00007199612,0.0002307735,0.00007745004,0.0003915576,0.0002365286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005297963,0.00001533174,0.9972031,0.00001404035,0.00004289775,0.0001479715,0.0007496009,0.0000490133,0.0001614739,0.00003458605,0.000403198,0.001125703],"study_design_scores_gemma":[0.000009820867,0.00001560895,0.9986057,0.00001078566,0.00002400015,0.00009274161,0.0006018128,0.0001200234,0.0000259936,0.00001374965,0.0004745133,0.000005459748],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997319,0.0002804197,0.00009804748,0.00008582426,0.000004796791,0.00003661416,0.001395596,0.000003883134,0.0007759172],"genre_scores_gemma":[0.9984666,0.0002176905,0.00008300343,0.00003647353,0.000002239236,0.00001486849,0.0006511831,0.000002570967,0.0005253421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01487029,"threshold_uncertainty_score":0.09362221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913784245494763,"score_gpt":0.283809996728672,"score_spread":0.2646721542737244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}