{"id":"W2169882453","doi":"10.1210/en.2013-1759","title":"Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Baboon; Biology; Fetus; PI3K/AKT/mTOR pathway; Phosphorylation; Internal medicine; Endocrinology; Mechanistic target of rapamycin; Protein kinase B; Signal transduction; Cell biology; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002317529,0.0001110256,0.0002971445,0.0001485979,0.00004609446,0.00000400429,0.0000337621,0.0001176546,0.00005459538],"category_scores_gemma":[0.0003529667,0.0001043361,0.00002516723,0.0001426824,0.000129804,0.00007663819,0.0000220813,0.0001792594,0.00001170188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001120284,"about_ca_system_score_gemma":0.00008368923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007548591,"about_ca_topic_score_gemma":0.0001443705,"domain_scores_codex":[0.9988326,0.000148337,0.0003667872,0.0002774381,0.0001239985,0.0002508374],"domain_scores_gemma":[0.9994112,0.00007221136,0.0001870962,0.0001613271,0.000094666,0.0000735174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001381809,0.0004423965,0.6604102,0.0005249701,0.00003747452,0.0000119397,0.0004590899,0.00000101236,0.1666734,0.1434757,0.001041449,0.02554053],"study_design_scores_gemma":[0.00338939,0.0005880507,0.9445668,0.00004676933,0.00001895868,0.00001977141,0.00003686119,0.0004676353,0.04151206,0.008150188,0.00110125,0.0001022282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995541,0.0005121007,0.0006652335,0.001099102,0.00009061116,0.0007581055,0.000006595969,0.0000381161,0.001289165],"genre_scores_gemma":[0.9961693,0.002648519,0.0008443838,0.0001192762,0.00005694454,0.00004586472,0.00004303742,0.000009795574,0.00006292442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2841566,"threshold_uncertainty_score":0.4254704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286792566690224,"score_gpt":0.2502401921867836,"score_spread":0.2373722665198813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}