{"id":"W2169883357","doi":"10.1017/s1462399410001572","title":"Drugs targeting Bcl-2 family members as an emerging strategy in cancer","year":2010,"lang":"en","type":"review","venue":"Expert Reviews in Molecular Medicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Health Canada; Canada Research Chairs; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Autophagy; Apoptosis; Endoplasmic reticulum; Programmed cell death; Cancer cell; Function (biology); Cancer; Cancer research; Bcl-2 family; Mitochondrion; Cell biology; Biology; Pharmacology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00150399,0.0007224728,0.002038205,0.000305572,0.00005568379,0.00001938653,0.0005047143,0.0008149942,0.0002066342],"category_scores_gemma":[0.0002068605,0.0005327325,0.0003654459,0.0004749175,0.0001034797,0.000009658977,0.000127651,0.0007209715,0.00001212012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009276414,"about_ca_system_score_gemma":0.0002528132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007986756,"about_ca_topic_score_gemma":0.0002359658,"domain_scores_codex":[0.995986,0.0006082517,0.001480976,0.00105061,0.0003451992,0.0005289336],"domain_scores_gemma":[0.9983607,0.00001791544,0.0005396947,0.0008270437,0.00005968563,0.0001949527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005556517,0.00004965753,7.346696e-7,0.001798003,0.00002465251,0.00005464731,0.0001811005,0.00001662234,0.04899198,0.00008952858,0.0006699164,0.9481176],"study_design_scores_gemma":[0.0004218306,0.0001617068,9.661144e-7,0.0115047,0.00008964243,0.00001955343,0.0001573857,0.00004542212,0.0003035603,0.00003782871,0.9867028,0.0005545887],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002172571,0.9957316,0.0002731775,0.00007639716,0.0006984646,0.001479094,0.000003446296,0.00001302366,0.001507536],"genre_scores_gemma":[0.00006307742,0.9958296,0.0007203772,0.0005979813,0.0008944076,0.0005685327,0.000794436,0.0001210143,0.0004106125],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9860329,"threshold_uncertainty_score":0.9997124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03660934570389299,"score_gpt":0.389342513383269,"score_spread":0.352733167679376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}